Usefulness of flourine-18-flourodeoxyglucose positron emission tomography in a patient with Takayasu's arteritis associated with antiphospholipid syndrome

Bunji Kaku, Takahiro Higuchi, Hounin Kanaya, Yuki Horita, Tsukasa Yamazaki, Yoshihide Uno, Hideki Itoh, Masanobu Namura, Masami Shimizu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A 36-year-old woman was admitted for recurring chest pain and hemoptysis. Blood pressure in the right and left arms was equal, and no murmurs or bruits were heard. Body temperature was normal on admission and remained within the normal range during the hospital stay. C-reactive protein was slightly elevated (2.3 mg/dL) and lupus anticoagulant was positive. Angiography showed no abnormality of the aorta or its branches, but the left pulmonary artery showed occlusion at the proximal portion. Computed tomography (CT) revealed segmental wall thickening of the thoracic aorta. Fluorine-18-fluorodeoxyglucose positron emission tomography (18FDG PET) showed high uptake in the proximal portion of the left pulmonary artery and in the thoracic aorta with wall thickening on CT. Based on these findings, a diagnosis of Takayasu's arteritis associated with antiphospholipid syndrome was made and high-dose steroid therapy (prednisolone 30 mg/day) was started. Two months later, the C-reactive protein level had decreased from 2.3 mg/dL to 1.1 mg/dL, and both the focal wall thickening and 18FDG uptake of the thoracic aorta were decreased. 18FDG PET was useful for evaluating the efficacy of the steroid therapy in addition to making a diagnosis of Takayasu's arteritis associated with antiphospholipid syndrome.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalInternational heart journal
Volume47
Issue number2
DOIs
Publication statusPublished - Apr 11 2006
Externally publishedYes

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Keywords

  • Antiphospholipid syndrome
  • Positron-emission tomography
  • Takayasu's arteritis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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