Usefulness and problems of endoscopic ultrasonography in prediction of the depth of tumor invasion in early gastric cancer

Takao Tsuzukr, Hiroyuki Okada, Yoshiro Kawahara, Junichiro Nasu, Ryuta Takenak, Masafumi Inoue, Seiji Kawano, Masahide Kita, Keisuke Hori, Kazuhide Yamamoto

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The objectives of this study were to evaluate the accuracy of endoscopic ultrasonography (EUS) in local and regional staging of early gastric cancer, to analyze the factors influencing the accuracy of EUS, and to reveal the usefulness and problems of EUS in pre-treatment staging of gastric cancer. We examined 105 lesions in 104 patients with histologically confirmed gastric cancer and retrospectively evaluated them with EUS. The diagnostic accuracy, sensitivity, and specificity of EUS were determined by comparing the pre-treatment EUS with the postoperative histopathological findings. The overall diagnostic accuracy of EUS for the depth of cancer invasion was 86%. The overall sensitivity and specificity were 60% and 96%, respectively. The accuracy significantly declined in lesions located in the upper-third of the stomach (70%). Type 0-1 lesions tended to be over-staged (12%), and the upper-third lesions tended to be under-staged (23%). The accuracy significantly declined in differentiated adenocarcinoma with massive submucosal invasion (56.5%). EUS is useful for evaluating the depth of gastric cancer invasion which determines the feasibility of endoscopic treatment. However, it is noteworthy that the diagnostic accuracy of the invasion depth diminished for lesions in the upper third of the stomach.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalActa medica Okayama
Volume65
Issue number2
Publication statusPublished - 2011

Keywords

  • Accuracy
  • Early gastric cancer
  • Endoscopic ultrasonography
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Usefulness and problems of endoscopic ultrasonography in prediction of the depth of tumor invasion in early gastric cancer'. Together they form a unique fingerprint.

  • Cite this