Use of artificial dermis and recombinant basic fibroblast growth factor for creating a neovagina in a patient with Mayer-Rokitansky-Küster-Hauser syndrome

Soichi Noguchi, Mikiya Nakatsuka, Yuka Sugiyama, Chebib Chekir, Yasuhiko Kamada, Yuji Hiramatsu

Research output: Contribution to journalArticle

41 Citations (Scopus)


Vaginal agenesis is an uncommon, but not rare, condition. Although there are many methods for creating a neo-vagina, the optimal treatment is unknown. An 18-year-old woman with Mayer-Rokitansky-Küster-Hauser syndrome received vaginoplasty with a modified Wharton procedure using an artificial dermis (atelocollagen sponge). From 10 days after the operation, the patient was administered human recombinant basic fibroblast growth factor (bFGF) spray to accelerate epithelialization on the neovagina. At 50 days after the operation, we confirmed histological squamous epithelialization of the vaginal epithelium. At 12 months after the operation, the neovagina was at least 3.5 cm in width and ∼8 cm in length. In this case, use of artificial dermis and recombinant bFGF to create a neovagina was an easy, less invasive and useful method.

Original languageEnglish
Pages (from-to)1629-1632
Number of pages4
JournalHuman Reproduction
Issue number7
Publication statusPublished - Jul 2004



  • Artificial dermis
  • Mayer-Rokitansky-Küster-Hauser syndrome
  • Vaginoplasty
  • bFGF

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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