Use of artificial dermis and recombinant basic fibroblast growth factor for creating a neovagina in a patient with Mayer-Rokitansky-Küster-Hauser syndrome

Soichi Noguchi, Mikiya Nakatsuka, Yuka Sugiyama, Chebib Chekir, Yasuhiko Kamada, Yuji Hiramatsu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Vaginal agenesis is an uncommon, but not rare, condition. Although there are many methods for creating a neo-vagina, the optimal treatment is unknown. An 18-year-old woman with Mayer-Rokitansky-Küster-Hauser syndrome received vaginoplasty with a modified Wharton procedure using an artificial dermis (atelocollagen sponge). From 10 days after the operation, the patient was administered human recombinant basic fibroblast growth factor (bFGF) spray to accelerate epithelialization on the neovagina. At 50 days after the operation, we confirmed histological squamous epithelialization of the vaginal epithelium. At 12 months after the operation, the neovagina was at least 3.5 cm in width and ∼8 cm in length. In this case, use of artificial dermis and recombinant bFGF to create a neovagina was an easy, less invasive and useful method.

Original languageEnglish
Pages (from-to)1629-1632
Number of pages4
JournalHuman Reproduction
Volume19
Issue number7
DOIs
Publication statusPublished - Jul 2004

Fingerprint

Fibroblast Growth Factor 2
Dermis
Porifera
Vagina
Epithelium
Therapeutics

Keywords

  • Artificial dermis
  • bFGF
  • Mayer-Rokitansky-Küster-Hauser syndrome
  • Vaginoplasty

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Use of artificial dermis and recombinant basic fibroblast growth factor for creating a neovagina in a patient with Mayer-Rokitansky-Küster-Hauser syndrome. / Noguchi, Soichi; Nakatsuka, Mikiya; Sugiyama, Yuka; Chekir, Chebib; Kamada, Yasuhiko; Hiramatsu, Yuji.

In: Human Reproduction, Vol. 19, No. 7, 07.2004, p. 1629-1632.

Research output: Contribution to journalArticle

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