Use of a Silkworm Larva Model in Phage Therapy Experiments

Jumpei Uchiyama; Iyo Takemura-Uchiyama; Shigenobu Matsuzaki

doi:10.1007/978-1-4939-8940-9_14

Use of a Silkworm Larva Model in Phage Therapy Experiments

Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shigenobu Matsuzaki

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Antibiotic-resistant bacteria can cause intractable infections in humans and animals, with damaging effects to health care and economics. Phage therapy is considered a possible alternative to chemotherapy for treating infections, but still requires laborious in vivo experiments before its introduction into society and its further development. Recently, silkworm larvae have been recognized as highly convenient and useful model animals, and an alternative to higher animals. We describe the procedure for experimental phage therapy to treat Staphylococcus aureus infections in silkworm larvae.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	173-181
Number of pages	9
DOIs	https://doi.org/10.1007/978-1-4939-8940-9_14
Publication status	Published - 2019
Externally published	Yes

Publication series

Name	Methods in Molecular Biology
Volume	1898
ISSN (Print)	1064-3745

Keywords

Animal model
Phage purification
Phage therapy
Silkworm larvae
Staphylococcus aureus

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/978-1-4939-8940-9_14

Cite this

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abstract = "Antibiotic-resistant bacteria can cause intractable infections in humans and animals, with damaging effects to health care and economics. Phage therapy is considered a possible alternative to chemotherapy for treating infections, but still requires laborious in vivo experiments before its introduction into society and its further development. Recently, silkworm larvae have been recognized as highly convenient and useful model animals, and an alternative to higher animals. We describe the procedure for experimental phage therapy to treat Staphylococcus aureus infections in silkworm larvae.",

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AU - Matsuzaki, Shigenobu

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AB - Antibiotic-resistant bacteria can cause intractable infections in humans and animals, with damaging effects to health care and economics. Phage therapy is considered a possible alternative to chemotherapy for treating infections, but still requires laborious in vivo experiments before its introduction into society and its further development. Recently, silkworm larvae have been recognized as highly convenient and useful model animals, and an alternative to higher animals. We describe the procedure for experimental phage therapy to treat Staphylococcus aureus infections in silkworm larvae.

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KW - Staphylococcus aureus

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Use of a Silkworm Larva Model in Phage Therapy Experiments

Abstract

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Keywords

ASJC Scopus subject areas

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