Use of a Silkworm Larva Model in Phage Therapy Experiments

Jumpei Uchiyama, Iyo Takemura-Uchiyama, Shigenobu Matsuzaki

Research output: Chapter in Book/Report/Conference proceedingChapter


Antibiotic-resistant bacteria can cause intractable infections in humans and animals, with damaging effects to health care and economics. Phage therapy is considered a possible alternative to chemotherapy for treating infections, but still requires laborious in vivo experiments before its introduction into society and its further development. Recently, silkworm larvae have been recognized as highly convenient and useful model animals, and an alternative to higher animals. We describe the procedure for experimental phage therapy to treat Staphylococcus aureus infections in silkworm larvae.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages9
Publication statusPublished - 2019
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Animal model
  • Phage purification
  • Phage therapy
  • Silkworm larvae
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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