Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury

Masami Tanaka, Hironori Nakura, Tomonori Tateishi, Minoru Watanabe, Sachiko Nakaya, Toshio Kumai, Shinichi Kobayashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Aims: Hydrophobic bile acids, such as deoxycholic acid produce cholestatic liver injury. Ursodeoxycholic acid has been shown to be useful in the treatment of cholestatic liver disease. Methods: In this study, we investigated the effects of deoxycholic acid or ursodeoxycholic acid (1% of diet, for 14 days) and their combination (1% each) on expression of hepatic cytochrome P450 isozymes, their related enzyme activities and mRNA level in rats. Results: Adding 1% deoxycholic acid to chow caused a marked increase in serum total bilirubin (47-fold) and total bile acid (8-fold) concentrations and in alkaline phosphatase (2.5-fold, p

Original languageEnglish
Pages (from-to)263-270
Number of pages8
JournalJournal of Hepatology
Volume31
Issue number2
DOIs
Publication statusPublished - Aug 1999
Externally publishedYes

Fingerprint

Ursodeoxycholic Acid
Deoxycholic Acid
Cytochrome P-450 Enzyme System
Isoenzymes
Bile Acids and Salts
Liver
Wounds and Injuries
Bilirubin
Alkaline Phosphatase
Liver Diseases
Diet
Messenger RNA
Enzymes
Serum

Keywords

  • Bile acids
  • Cytochrome P450
  • Deoxycholic acid
  • Drug-metabolizing system
  • Liver injury
  • Ursodeoxycholic acid

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury. / Tanaka, Masami; Nakura, Hironori; Tateishi, Tomonori; Watanabe, Minoru; Nakaya, Sachiko; Kumai, Toshio; Kobayashi, Shinichi.

In: Journal of Hepatology, Vol. 31, No. 2, 08.1999, p. 263-270.

Research output: Contribution to journalArticle

Tanaka, Masami ; Nakura, Hironori ; Tateishi, Tomonori ; Watanabe, Minoru ; Nakaya, Sachiko ; Kumai, Toshio ; Kobayashi, Shinichi. / Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury. In: Journal of Hepatology. 1999 ; Vol. 31, No. 2. pp. 263-270.
@article{cca977f74f6446ce82ddaeb91718e33c,
title = "Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury",
abstract = "Background/Aims: Hydrophobic bile acids, such as deoxycholic acid produce cholestatic liver injury. Ursodeoxycholic acid has been shown to be useful in the treatment of cholestatic liver disease. Methods: In this study, we investigated the effects of deoxycholic acid or ursodeoxycholic acid (1{\%} of diet, for 14 days) and their combination (1{\%} each) on expression of hepatic cytochrome P450 isozymes, their related enzyme activities and mRNA level in rats. Results: Adding 1{\%} deoxycholic acid to chow caused a marked increase in serum total bilirubin (47-fold) and total bile acid (8-fold) concentrations and in alkaline phosphatase (2.5-fold, p",
keywords = "Bile acids, Cytochrome P450, Deoxycholic acid, Drug-metabolizing system, Liver injury, Ursodeoxycholic acid",
author = "Masami Tanaka and Hironori Nakura and Tomonori Tateishi and Minoru Watanabe and Sachiko Nakaya and Toshio Kumai and Shinichi Kobayashi",
year = "1999",
month = "8",
doi = "10.1016/S0168-8278(99)80223-2",
language = "English",
volume = "31",
pages = "263--270",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury

AU - Tanaka, Masami

AU - Nakura, Hironori

AU - Tateishi, Tomonori

AU - Watanabe, Minoru

AU - Nakaya, Sachiko

AU - Kumai, Toshio

AU - Kobayashi, Shinichi

PY - 1999/8

Y1 - 1999/8

N2 - Background/Aims: Hydrophobic bile acids, such as deoxycholic acid produce cholestatic liver injury. Ursodeoxycholic acid has been shown to be useful in the treatment of cholestatic liver disease. Methods: In this study, we investigated the effects of deoxycholic acid or ursodeoxycholic acid (1% of diet, for 14 days) and their combination (1% each) on expression of hepatic cytochrome P450 isozymes, their related enzyme activities and mRNA level in rats. Results: Adding 1% deoxycholic acid to chow caused a marked increase in serum total bilirubin (47-fold) and total bile acid (8-fold) concentrations and in alkaline phosphatase (2.5-fold, p

AB - Background/Aims: Hydrophobic bile acids, such as deoxycholic acid produce cholestatic liver injury. Ursodeoxycholic acid has been shown to be useful in the treatment of cholestatic liver disease. Methods: In this study, we investigated the effects of deoxycholic acid or ursodeoxycholic acid (1% of diet, for 14 days) and their combination (1% each) on expression of hepatic cytochrome P450 isozymes, their related enzyme activities and mRNA level in rats. Results: Adding 1% deoxycholic acid to chow caused a marked increase in serum total bilirubin (47-fold) and total bile acid (8-fold) concentrations and in alkaline phosphatase (2.5-fold, p

KW - Bile acids

KW - Cytochrome P450

KW - Deoxycholic acid

KW - Drug-metabolizing system

KW - Liver injury

KW - Ursodeoxycholic acid

UR - http://www.scopus.com/inward/record.url?scp=0032776444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032776444&partnerID=8YFLogxK

U2 - 10.1016/S0168-8278(99)80223-2

DO - 10.1016/S0168-8278(99)80223-2

M3 - Article

VL - 31

SP - 263

EP - 270

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 2

ER -