Uroguanylin level in umbilical cord blood

Hirokazu Tsukahara, K. Sekine, M. Uchiyama, M. Miura, M. Nakazato, Y. Date, W. Tsunezawa, F. Kotsuji, K. Nishida, M. Hiraoka, M. Mayumi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalPediatrics International
Volume43
Issue number3
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Fetal Blood
Osmolar Concentration
Natriuretic Peptides
Umbilical Cord
Serum
Diuretics
Radioimmunoassay
uroguanylin
Reference Values
Urine
Kidney
Peptides

Keywords

  • Natriuretic peptide
  • Newborn
  • Transition
  • Umbilical cord blood
  • Uroguanylin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Tsukahara, H., Sekine, K., Uchiyama, M., Miura, M., Nakazato, M., Date, Y., ... Mayumi, M. (2001). Uroguanylin level in umbilical cord blood. Pediatrics International, 43(3), 267-269. https://doi.org/10.1046/j.1442-200X.2001.01393.x

Uroguanylin level in umbilical cord blood. / Tsukahara, Hirokazu; Sekine, K.; Uchiyama, M.; Miura, M.; Nakazato, M.; Date, Y.; Tsunezawa, W.; Kotsuji, F.; Nishida, K.; Hiraoka, M.; Mayumi, M.

In: Pediatrics International, Vol. 43, No. 3, 2001, p. 267-269.

Research output: Contribution to journalArticle

Tsukahara, H, Sekine, K, Uchiyama, M, Miura, M, Nakazato, M, Date, Y, Tsunezawa, W, Kotsuji, F, Nishida, K, Hiraoka, M & Mayumi, M 2001, 'Uroguanylin level in umbilical cord blood', Pediatrics International, vol. 43, no. 3, pp. 267-269. https://doi.org/10.1046/j.1442-200X.2001.01393.x
Tsukahara H, Sekine K, Uchiyama M, Miura M, Nakazato M, Date Y et al. Uroguanylin level in umbilical cord blood. Pediatrics International. 2001;43(3):267-269. https://doi.org/10.1046/j.1442-200X.2001.01393.x
Tsukahara, Hirokazu ; Sekine, K. ; Uchiyama, M. ; Miura, M. ; Nakazato, M. ; Date, Y. ; Tsunezawa, W. ; Kotsuji, F. ; Nishida, K. ; Hiraoka, M. ; Mayumi, M. / Uroguanylin level in umbilical cord blood. In: Pediatrics International. 2001 ; Vol. 43, No. 3. pp. 267-269.
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