Uroguanylin level in umbilical cord blood

Hirokazu Tsukahara; K. Sekine; M. Uchiyama; M. Miura; M. Nakazato; Y. Date; W. Tsunezawa; F. Kotsuji; K. Nishida; M. Hiraoka; M. Mayumi

doi:10.1046/j.1442-200X.2001.01393.x

Uroguanylin level in umbilical cord blood

Hirokazu Tsukahara, K. Sekine, M. Uchiyama, M. Miura, M. Nakazato, Y. Date, W. Tsunezawa, F. Kotsuji, K. Nishida, M. Hiraoka, M. Mayumi

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.

Original language	English
Pages (from-to)	267-269
Number of pages	3
Journal	Pediatrics International
Volume	43
Issue number	3
DOIs	https://doi.org/10.1046/j.1442-200X.2001.01393.x
Publication status	Published - 2001
Externally published	Yes

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Keywords

Natriuretic peptide
Newborn
Transition
Umbilical cord blood
Uroguanylin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

Tsukahara, H., Sekine, K., Uchiyama, M., Miura, M., Nakazato, M., Date, Y., Tsunezawa, W., Kotsuji, F., Nishida, K., Hiraoka, M., & Mayumi, M. (2001). Uroguanylin level in umbilical cord blood. Pediatrics International, 43(3), 267-269. https://doi.org/10.1046/j.1442-200X.2001.01393.x

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abstract = "Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.",

keywords = "Natriuretic peptide, Newborn, Transition, Umbilical cord blood, Uroguanylin",

author = "Hirokazu Tsukahara and K. Sekine and M. Uchiyama and M. Miura and M. Nakazato and Y. Date and W. Tsunezawa and F. Kotsuji and K. Nishida and M. Hiraoka and M. Mayumi",

year = "2001",

doi = "10.1046/j.1442-200X.2001.01393.x",

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T1 - Uroguanylin level in umbilical cord blood

AU - Tsukahara, Hirokazu

AU - Sekine, K.

AU - Uchiyama, M.

AU - Miura, M.

AU - Nakazato, M.

AU - Date, Y.

AU - Tsunezawa, W.

AU - Kotsuji, F.

AU - Nishida, K.

AU - Hiraoka, M.

AU - Mayumi, M.

PY - 2001

Y1 - 2001

N2 - Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.

AB - Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.

KW - Natriuretic peptide

KW - Newborn

KW - Transition

KW - Umbilical cord blood

KW - Uroguanylin

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Access to Document

10.1046/j.1442-200X.2001.01393.x