Uroguanylin level in umbilical cord blood

H. Tsukahara, K. Sekine, M. Uchiyama, M. Miura, M. Nakazato, Y. Date, W. Tsunezawa, F. Kotsuji, K. Nishida, M. Hiraoka, M. Mayumi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalPediatrics International
Volume43
Issue number3
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

Keywords

  • Natriuretic peptide
  • Newborn
  • Transition
  • Umbilical cord blood
  • Uroguanylin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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  • Cite this

    Tsukahara, H., Sekine, K., Uchiyama, M., Miura, M., Nakazato, M., Date, Y., Tsunezawa, W., Kotsuji, F., Nishida, K., Hiraoka, M., & Mayumi, M. (2001). Uroguanylin level in umbilical cord blood. Pediatrics International, 43(3), 267-269. https://doi.org/10.1046/j.1442-200X.2001.01393.x