Abstract
Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
Original language | English |
---|---|
Pages (from-to) | 267-269 |
Number of pages | 3 |
Journal | Pediatrics International |
Volume | 43 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2001 |
Externally published | Yes |
Keywords
- Natriuretic peptide
- Newborn
- Transition
- Umbilical cord blood
- Uroguanylin
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health