Abstract
Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
| Original language | English |
|---|---|
| Pages (from-to) | 267-269 |
| Number of pages | 3 |
| Journal | Pediatrics International |
| Volume | 43 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
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Keywords
- Natriuretic peptide
- Newborn
- Transition
- Umbilical cord blood
- Uroguanylin
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Uroguanylin level in umbilical cord blood. / Tsukahara, Hirokazu; Sekine, K.; Uchiyama, M.; Miura, M.; Nakazato, M.; Date, Y.; Tsunezawa, W.; Kotsuji, F.; Nishida, K.; Hiraoka, M.; Mayumi, M.
In: Pediatrics International, Vol. 43, No. 3, 2001, p. 267-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uroguanylin level in umbilical cord blood
AU - Tsukahara, Hirokazu
AU - Sekine, K.
AU - Uchiyama, M.
AU - Miura, M.
AU - Nakazato, M.
AU - Date, Y.
AU - Tsunezawa, W.
AU - Kotsuji, F.
AU - Nishida, K.
AU - Hiraoka, M.
AU - Mayumi, M.
PY - 2001
Y1 - 2001
N2 - Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
AB - Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
KW - Natriuretic peptide
KW - Newborn
KW - Transition
KW - Umbilical cord blood
KW - Uroguanylin
UR - http://www.scopus.com/inward/record.url?scp=0034938291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034938291&partnerID=8YFLogxK
U2 - 10.1046/j.1442-200X.2001.01393.x
DO - 10.1046/j.1442-200X.2001.01393.x
M3 - Article
C2 - 11380922
AN - SCOPUS:0034938291
VL - 43
SP - 267
EP - 269
JO - Pediatrics International
JF - Pediatrics International
SN - 1328-8067
IS - 3
ER -