Urinary uric acid excretion in term and premature infants

H. Tsukahara, M. Hiraoka, C. Hori, S. Tsuchida, H. Uchida, K. Fujisawa, Y. Konishi, M. Sudo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To clarify postnatal changes in urinary uric acid (UA) excretion in normal term infants and to examine the effects of prematurity or illness on the UA excretion. Methodology: Measurements of urinary UA were performed in term and premature infants at the ages of 1 and 7 days and at 1 and 4 months, as well as at 7 months in term infants. Results: Urinary UA levels were lowest on day 7 in term infants. The levels were highest on day 1 in premature infants and remained significantly higher compared to term babies during the first month of life. Respiratory failure requiring ventilation and oxygen supply resulted in further significant elevation of urinary UA in premature infants. Conclusions: With the reference values obtained in the study reported here, urinary UA can now be used for the diagnosis and monitoring of inherited disorders of purine metabolism and for the assessment of oxygen radical insult to sick infants.

Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalJournal of Paediatrics and Child Health
Volume32
Issue number4
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

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Keywords

  • Infants
  • Oxygen radical
  • Prematurity
  • Purine metabolism
  • Uric acid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Tsukahara, H., Hiraoka, M., Hori, C., Tsuchida, S., Uchida, H., Fujisawa, K., Konishi, Y., & Sudo, M. (1996). Urinary uric acid excretion in term and premature infants. Journal of Paediatrics and Child Health, 32(4), 330-332. https://doi.org/10.1111/j.1440-1754.1996.tb02564.x