Urinary selenium excretion in infancy: Comparison between term and preterm infants

Hirokazu Tsukahara, Yoji Deguchi, Masahiro Hiraoka, Chikahide Hori, Keiko Kimura, Tooru Kawamitsu, Yukuo Konishi, Yukinori Kusaka, Masakatsu Sudo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We evaluated the urinary excretion of selenium (Se), an essential component of glutathione peroxidase, in infants aged 1 week and 1, 4, and 7 months and examined the relationship between urinary Se and renal function. Daytime spot urine samples from a total of 80 infants were analyzed. The Se concentration in urine was measured by fluorometry, while the β2-microglobulin content, an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, the urinary Se excretion showed a peak level at 1 month of age. In contrast, the urinary Se concentration rapidly decreased in preterm infants from 1 week to 7 months postnatally. The level at 1 week in preterm infants was significantly higher than that in term infants, although the mean levels at 1, 4, and 7 months were lower in preterm infants. The level of urinary Se did not correlate significantly with the β2-microglobulin concentration, either in term or preterm infants at any age investigated. Our results suggest that the renal excretion of Se probably reflects the body stores of Se and is not related directly to the renal function in infants. Urinary Se, a noninvasive marker of the Se status, may be used for diagnosis and follow-up of Se deficiency in infants.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalBiology of the Neonate
Volume70
Issue number1
Publication statusPublished - Jul 1996
Externally publishedYes

Fingerprint

Selenium
Premature Infants
Kidney
Urine
Fluorometry
Glutathione Peroxidase
Radioimmunoassay

Keywords

  • β-microglobulin
  • Infants
  • Renal function
  • Selenium
  • Urinary selenium excretion

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Tsukahara, H., Deguchi, Y., Hiraoka, M., Hori, C., Kimura, K., Kawamitsu, T., ... Sudo, M. (1996). Urinary selenium excretion in infancy: Comparison between term and preterm infants. Biology of the Neonate, 70(1), 35-40.

Urinary selenium excretion in infancy : Comparison between term and preterm infants. / Tsukahara, Hirokazu; Deguchi, Yoji; Hiraoka, Masahiro; Hori, Chikahide; Kimura, Keiko; Kawamitsu, Tooru; Konishi, Yukuo; Kusaka, Yukinori; Sudo, Masakatsu.

In: Biology of the Neonate, Vol. 70, No. 1, 07.1996, p. 35-40.

Research output: Contribution to journalArticle

Tsukahara, H, Deguchi, Y, Hiraoka, M, Hori, C, Kimura, K, Kawamitsu, T, Konishi, Y, Kusaka, Y & Sudo, M 1996, 'Urinary selenium excretion in infancy: Comparison between term and preterm infants', Biology of the Neonate, vol. 70, no. 1, pp. 35-40.
Tsukahara H, Deguchi Y, Hiraoka M, Hori C, Kimura K, Kawamitsu T et al. Urinary selenium excretion in infancy: Comparison between term and preterm infants. Biology of the Neonate. 1996 Jul;70(1):35-40.
Tsukahara, Hirokazu ; Deguchi, Yoji ; Hiraoka, Masahiro ; Hori, Chikahide ; Kimura, Keiko ; Kawamitsu, Tooru ; Konishi, Yukuo ; Kusaka, Yukinori ; Sudo, Masakatsu. / Urinary selenium excretion in infancy : Comparison between term and preterm infants. In: Biology of the Neonate. 1996 ; Vol. 70, No. 1. pp. 35-40.
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