TY - JOUR
T1 - Urinary Selenium Excretion in Infancy
T2 - Comparison between Term and Preterm Infants
AU - Tsukahara, Hirokazu
AU - Deguchi, Yoji
AU - Hiraoka, Masahiro
AU - Hori, Chikahide
AU - Kimura, Keiko
AU - Kawamitsu, Tooru
AU - Konishi, Yukuo
AU - Kusaka, Yukinori
AU - Sudo, Masakatsu
PY - 1996
Y1 - 1996
N2 - We evaluated the urinary excretion of selenium (Se), an essential component of glutathione peroxidase, in infants aged 1 week and 1, 4, and 7 months and examined the relationship between urinary Se and renal function. Daytime spot urine samples from a total of 80 infants were analyzed. The Se concentration in urine was measured by fluorometry, while the β2-microglobulin content, an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, the urinary Se excretion showed a peak level at 1 month of age. In contrast, the urinary Se concentration rapidly decreased in preterm infants from 1 week to 7 months postnatally. The level at 1 week in preterm infants was significantly higher than that in term infants, although the mean levels at 1 4, and 7 months were lower in preterm infants. The level of urinary Se did not correlate significantly with the β2-microglobulin concentration, either in term or preterm infants at any age investigated. Our results suggest that the renal excretion of Se probably reflects the body stores of Se and is not related directly to the renal function in infants. Urinary Se, a noninvasive marker of the Se status, may be used for diagnosis and follow-up of Se deficiency in infants.
AB - We evaluated the urinary excretion of selenium (Se), an essential component of glutathione peroxidase, in infants aged 1 week and 1, 4, and 7 months and examined the relationship between urinary Se and renal function. Daytime spot urine samples from a total of 80 infants were analyzed. The Se concentration in urine was measured by fluorometry, while the β2-microglobulin content, an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, the urinary Se excretion showed a peak level at 1 month of age. In contrast, the urinary Se concentration rapidly decreased in preterm infants from 1 week to 7 months postnatally. The level at 1 week in preterm infants was significantly higher than that in term infants, although the mean levels at 1 4, and 7 months were lower in preterm infants. The level of urinary Se did not correlate significantly with the β2-microglobulin concentration, either in term or preterm infants at any age investigated. Our results suggest that the renal excretion of Se probably reflects the body stores of Se and is not related directly to the renal function in infants. Urinary Se, a noninvasive marker of the Se status, may be used for diagnosis and follow-up of Se deficiency in infants.
KW - Infants
KW - Renal function
KW - Selenium
KW - Urinary selenium excretion
KW - βMicroglobulin
UR - http://www.scopus.com/inward/record.url?scp=0029846127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029846127&partnerID=8YFLogxK
U2 - 10.1159/000244346
DO - 10.1159/000244346
M3 - Article
C2 - 8853845
AN - SCOPUS:0029846127
VL - 70
SP - 35
EP - 40
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 1
ER -