Urinary nitrite/nitrate excretion in infancy: Comparison between term and preterm infants

Hirokazu Tsukahara, Masahiro Hiraoka, Chikahide Hori, Shinya Tsuchida, Ikeue Hata, Kouichi Nishida, Kiyoshi Kikuchi, Masakatsu Sudo

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


We measured urinary nitrite/nitrate (NOx-) excretion, an index of endogenous nitric oxide formation, in term and preterm infants aged 1 week and 1, 4, 7 months, In normal term infants, urinary NOx- excretion increased from 1 week to 1 month and then decreased until 4 months where it stabilized thereafter. Urinary NOx- excretion in preterm infants was significantly higher compared with term infants at 1 week of age. This finding suggests that the nitric oxide pathway in preterm infants may be activated compared with term infants in early life. With the reference values obtained in this study, this urinary marker can now be used for identifying infants with abnormal nitric oxide production.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalEarly Human Development
Issue number1
Publication statusPublished - 1997
Externally publishedYes


  • Infant
  • NO and NO
  • Nitric oxide
  • Urine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


Dive into the research topics of 'Urinary nitrite/nitrate excretion in infancy: Comparison between term and preterm infants'. Together they form a unique fingerprint.

Cite this