Urinary nitrite/nitrate excretion in infancy: Comparison between term and preterm infants

Hirokazu Tsukahara; Masahiro Hiraoka; Chikahide Hori; Shinya Tsuchida; Ikeue Hata; Kouichi Nishida; Kiyoshi Kikuchi; Masakatsu Sudo

doi:10.1016/S0378-3782(96)01768-9

Urinary nitrite/nitrate excretion in infancy: Comparison between term and preterm infants

Hirokazu Tsukahara, Masahiro Hiraoka, Chikahide Hori, Shinya Tsuchida, Ikeue Hata, Kouichi Nishida, Kiyoshi Kikuchi, Masakatsu Sudo

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We measured urinary nitrite/nitrate (NOx^-) excretion, an index of endogenous nitric oxide formation, in term and preterm infants aged 1 week and 1, 4, 7 months, In normal term infants, urinary NOx^- excretion increased from 1 week to 1 month and then decreased until 4 months where it stabilized thereafter. Urinary NOx^- excretion in preterm infants was significantly higher compared with term infants at 1 week of age. This finding suggests that the nitric oxide pathway in preterm infants may be activated compared with term infants in early life. With the reference values obtained in this study, this urinary marker can now be used for identifying infants with abnormal nitric oxide production.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Early Human Development
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/S0378-3782(96)01768-9
Publication status	Published - 1997
Externally published	Yes

Keywords

Infant
NO and NO
Nitric oxide
Urine

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

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10.1016/S0378-3782(96)01768-9

Cite this

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title = "Urinary nitrite/nitrate excretion in infancy: Comparison between term and preterm infants",

abstract = "We measured urinary nitrite/nitrate (NOx-) excretion, an index of endogenous nitric oxide formation, in term and preterm infants aged 1 week and 1, 4, 7 months, In normal term infants, urinary NOx- excretion increased from 1 week to 1 month and then decreased until 4 months where it stabilized thereafter. Urinary NOx- excretion in preterm infants was significantly higher compared with term infants at 1 week of age. This finding suggests that the nitric oxide pathway in preterm infants may be activated compared with term infants in early life. With the reference values obtained in this study, this urinary marker can now be used for identifying infants with abnormal nitric oxide production.",

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T1 - Urinary nitrite/nitrate excretion in infancy

T2 - Comparison between term and preterm infants

AU - Tsukahara, Hirokazu

AU - Hiraoka, Masahiro

AU - Hori, Chikahide

AU - Tsuchida, Shinya

AU - Hata, Ikeue

AU - Nishida, Kouichi

AU - Kikuchi, Kiyoshi

AU - Sudo, Masakatsu

PY - 1997

Y1 - 1997

N2 - We measured urinary nitrite/nitrate (NOx-) excretion, an index of endogenous nitric oxide formation, in term and preterm infants aged 1 week and 1, 4, 7 months, In normal term infants, urinary NOx- excretion increased from 1 week to 1 month and then decreased until 4 months where it stabilized thereafter. Urinary NOx- excretion in preterm infants was significantly higher compared with term infants at 1 week of age. This finding suggests that the nitric oxide pathway in preterm infants may be activated compared with term infants in early life. With the reference values obtained in this study, this urinary marker can now be used for identifying infants with abnormal nitric oxide production.

AB - We measured urinary nitrite/nitrate (NOx-) excretion, an index of endogenous nitric oxide formation, in term and preterm infants aged 1 week and 1, 4, 7 months, In normal term infants, urinary NOx- excretion increased from 1 week to 1 month and then decreased until 4 months where it stabilized thereafter. Urinary NOx- excretion in preterm infants was significantly higher compared with term infants at 1 week of age. This finding suggests that the nitric oxide pathway in preterm infants may be activated compared with term infants in early life. With the reference values obtained in this study, this urinary marker can now be used for identifying infants with abnormal nitric oxide production.

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KW - Nitric oxide

KW - Urine

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Urinary nitrite/nitrate excretion in infancy: Comparison between term and preterm infants

Abstract

Keywords

ASJC Scopus subject areas

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