Urinary hydrogen peroxide as biomarker

Da Hong Wang; Keiki Ogino; Yoshie Sato; Noriko Sakano; Masayuki Kubo; Kei Takemoto; Chie Masatomi

doi:10.1007/978-94-007-7696-8_43

Urinary hydrogen peroxide as biomarker

Da Hong Wang, Keiki Ogino, Yoshie Sato, Noriko Sakano, Masayuki Kubo, Kei Takemoto, Chie Masatomi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H₂O₂ excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H₂O₂ in human. We also give a brief overview on the association of urinary levels of H₂O₂ with other oxidative stress biomarkers and discuss the possibility whether urinary H₂O₂ could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.

Original language	English
Title of host publication	General Methods in Biomarker Research and their Applications
Publisher	Springer International Publishing
Pages	313-331
Number of pages	19
Volume	1-2
ISBN (Electronic)	9789400776968
ISBN (Print)	9789400776951
DOIs	https://doi.org/10.1007/978-94-007-7696-8_43
Publication status	Published - Sep 2 2015

ASJC Scopus subject areas

Medicine(all)

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abstract = "Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as {"}a signaling molecule{"} to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.",

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AU - Wang, Da Hong

AU - Ogino, Keiki

AU - Sato, Yoshie

AU - Sakano, Noriko

AU - Kubo, Masayuki

AU - Takemoto, Kei

AU - Masatomi, Chie

PY - 2015/9/2

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N2 - Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.

AB - Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.

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