Urinary hydrogen peroxide as biomarker

Da Hong Wang, Keiki Ogino, Yoshie Sato, Noriko Sakano, Masayuki Kubo, Kei Takemoto, Chie Masatomi

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.

Original languageEnglish
Title of host publicationGeneral Methods in Biomarker Research and their Applications
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9789400776968
ISBN (Print)9789400776951
Publication statusPublished - Sep 2 2015

ASJC Scopus subject areas

  • Medicine(all)


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