Abstract
Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.
| Original language | English |
|---|---|
| Title of host publication | General Methods in Biomarker Research and their Applications |
| Publisher | Springer International Publishing |
| Pages | 313-331 |
| Number of pages | 19 |
| Volume | 1-2 |
| ISBN (Print) | 9789400776968, 9789400776951 |
| DOIs | |
| Publication status | Published - Sep 2 2015 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Urinary hydrogen peroxide as biomarker. / Wang, Da Hong; Ogino, Keiki; Sato, Yoshie; Sakano, Noriko; Kubo, Masayuki; Takemoto, Kei; Masatomi, Chie.
General Methods in Biomarker Research and their Applications. Vol. 1-2 Springer International Publishing, 2015. p. 313-331.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Urinary hydrogen peroxide as biomarker
AU - Wang, Da Hong
AU - Ogino, Keiki
AU - Sato, Yoshie
AU - Sakano, Noriko
AU - Kubo, Masayuki
AU - Takemoto, Kei
AU - Masatomi, Chie
PY - 2015/9/2
Y1 - 2015/9/2
N2 - Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.
AB - Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.
UR - http://www.scopus.com/inward/record.url?scp=84958699374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958699374&partnerID=8YFLogxK
U2 - 10.1007/978-94-007-7696-8_43
DO - 10.1007/978-94-007-7696-8_43
M3 - Chapter
AN - SCOPUS:84958699374
SN - 9789400776968
SN - 9789400776951
VL - 1-2
SP - 313
EP - 331
BT - General Methods in Biomarker Research and their Applications
PB - Springer International Publishing
ER -