Hydrogen peroxide can be found in human urine, not only in persons with diseases, but also in healthy individuals. In the body, hydrogen peroxide plays dual roles: on the one hand, it can produce more dangerous reactive oxygen species - hydroxyl radicals, which cause damage to the cells; on the other hand, it is considered as "a signaling molecule" to regulate the cellular processes. In this chapter, we will review the literature linking H2O2 excretion in urine of healthy individuals and of persons with diseases and present the available methods that have been used for detection of urinary H2O2 in human. We also give a brief overview on the association of urinary levels of H2O2 with other oxidative stress biomarkers and discuss the possibility whether urinary H2O2 could be a useful biomarker for the assessment of the oxidative status in human and for the prediction of the pathogenesis and progression of diseases.
|Title of host publication||General Methods in Biomarker Research and their Applications|
|Publisher||Springer International Publishing|
|Number of pages||19|
|Publication status||Published - Sep 2 2015|
ASJC Scopus subject areas