Urinary growth hormone excretion in preterm neonates

Hirokazu Tsukahara, Yasushi Fujii, Masanori Kuriyama, Shinya Tsuchida, Masahiro Hiraoka, Kiyoshi Kikuch, Masakatsu Sudo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We measured urinary growth hormone (U-GH), β2micro-globulin (U-B2) and serum growth hormone (S-GH) in preterm neonates on days 1. 4, 7, 14 and 28 of age. U-GH as well as U-B2 were high, particularly in the more premature and sick neonates with respiratory failure requiring mechanical ventilation. U-GH showed significant positive correlations with U-B2 throughout the study but with S-GH only on day 7. Therefore, we conclude that in preterm neonates, U-GH mainly reflects the degree of renal proximal tubular function, which is determined by the degree of renal maturation of the subject and of tubular injury due to disease states such as respiratory failure.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalNeonatology
Volume63
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • Preterm neonate
  • Renal proximal tubular function
  • Respiratory distress syndrome
  • Respiratory failure
  • Ultrasensitive sandwich enzyme immunoassay
  • Urinary growth hormone
  • Urinary β<inf>2</inf>-microglobulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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