Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women

Chie Masatomi, Kaori Imai, Da Hong Wang, Satoru Ikeda, Kazuhisa Taketa, Shinji Takata, Shohei Kira

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5% of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalActa Medica Okayama
Volume53
Issue number3
Publication statusPublished - 1999

Fingerprint

Collagen Type I
Life Style
Bone
Exercise
Bone and Bones
Stiffness
Acoustic wave velocity
Ultrasonics
Beverages
Osteocalcin
Minerals
Alkaline Phosphatase
Creatinine
Menopause
Collagen
Bone Density
Alcohols
Osteoporosis
Habits
Calcium

Keywords

  • Bone turnover
  • Lifestyle
  • Menopause
  • N-telopeptides
  • Osteoporosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Masatomi, C., Imai, K., Wang, D. H., Ikeda, S., Taketa, K., Takata, S., & Kira, S. (1999). Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women. Acta Medica Okayama, 53(3), 133-140.

Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women. / Masatomi, Chie; Imai, Kaori; Wang, Da Hong; Ikeda, Satoru; Taketa, Kazuhisa; Takata, Shinji; Kira, Shohei.

In: Acta Medica Okayama, Vol. 53, No. 3, 1999, p. 133-140.

Research output: Contribution to journalArticle

Masatomi, C, Imai, K, Wang, DH, Ikeda, S, Taketa, K, Takata, S & Kira, S 1999, 'Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women', Acta Medica Okayama, vol. 53, no. 3, pp. 133-140.
Masatomi, Chie ; Imai, Kaori ; Wang, Da Hong ; Ikeda, Satoru ; Taketa, Kazuhisa ; Takata, Shinji ; Kira, Shohei. / Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women. In: Acta Medica Okayama. 1999 ; Vol. 53, No. 3. pp. 133-140.
@article{9d6245319af2497e86f983703a620802,
title = "Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women",
abstract = "The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5{\%} of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.",
keywords = "Bone turnover, Lifestyle, Menopause, N-telopeptides, Osteoporosis",
author = "Chie Masatomi and Kaori Imai and Wang, {Da Hong} and Satoru Ikeda and Kazuhisa Taketa and Shinji Takata and Shohei Kira",
year = "1999",
language = "English",
volume = "53",
pages = "133--140",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "3",

}

TY - JOUR

T1 - Urinary excretion of type I collagen cross-linked N-telopeptides, bone mass and related lifestyle in middle-aged women

AU - Masatomi, Chie

AU - Imai, Kaori

AU - Wang, Da Hong

AU - Ikeda, Satoru

AU - Taketa, Kazuhisa

AU - Takata, Shinji

AU - Kira, Shohei

PY - 1999

Y1 - 1999

N2 - The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5% of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.

AB - The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5% of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.

KW - Bone turnover

KW - Lifestyle

KW - Menopause

KW - N-telopeptides

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=0033145690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033145690&partnerID=8YFLogxK

M3 - Article

C2 - 10410791

AN - SCOPUS:0033145690

VL - 53

SP - 133

EP - 140

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 3

ER -