TY - JOUR
T1 - Urinary excretion of pyridinium cross-links of collagen in infancy
AU - Tsukahara, Hirokazu
AU - Miura, Masakazu
AU - Hori, Chikahide
AU - Hiraoka, Masahiro
AU - Nosaka, Kazuhiko
AU - Hata, Keishi
AU - Konishi, Yukuo
AU - Sudo, Masakatsu
PY - 1996
Y1 - 1996
N2 - This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.
AB - This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.
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U2 - 10.1016/S0026-0495(96)90228-0
DO - 10.1016/S0026-0495(96)90228-0
M3 - Article
C2 - 8609840
AN - SCOPUS:0029939223
VL - 45
SP - 510
EP - 514
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 4
ER -