Abstract
This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.
| Original language | English |
|---|---|
| Pages (from-to) | 510-514 |
| Number of pages | 5 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Urinary excretion of pyridinium cross-links of collagen in infancy. / Tsukahara, Hirokazu; Miura, Masakazu; Hori, Chikahide; Hiraoka, Masahiro; Nosaka, Kazuhiko; Hata, Keishi; Konishi, Yukuo; Sudo, Masakatsu.
In: Metabolism: Clinical and Experimental, Vol. 45, No. 4, 1996, p. 510-514.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urinary excretion of pyridinium cross-links of collagen in infancy
AU - Tsukahara, Hirokazu
AU - Miura, Masakazu
AU - Hori, Chikahide
AU - Hiraoka, Masahiro
AU - Nosaka, Kazuhiko
AU - Hata, Keishi
AU - Konishi, Yukuo
AU - Sudo, Masakatsu
PY - 1996
Y1 - 1996
N2 - This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.
AB - This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029939223&partnerID=8YFLogxK
U2 - 10.1016/S0026-0495(96)90228-0
DO - 10.1016/S0026-0495(96)90228-0
M3 - Article
VL - 45
SP - 510
EP - 514
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 4
ER -