Urinary excretion of pyridinium cross-links of collagen in infancy

Hirokazu Tsukahara, Masakazu Miura, Chikahide Hori, Masahiro Hiraoka, Kazuhiko Nosaka, Keishi Hata, Yukuo Konishi, Masakatsu Sudo

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.

Original languageEnglish
Pages (from-to)510-514
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume45
Issue number4
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Collagen
Kidney
Premature Infants
Bone Remodeling
Bone Resorption
Radioimmunoassay
Cross-Sectional Studies
Fluorescence
High Pressure Liquid Chromatography
Urine
Growth
pyridinoline
deoxypyridinoline

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Urinary excretion of pyridinium cross-links of collagen in infancy. / Tsukahara, Hirokazu; Miura, Masakazu; Hori, Chikahide; Hiraoka, Masahiro; Nosaka, Kazuhiko; Hata, Keishi; Konishi, Yukuo; Sudo, Masakatsu.

In: Metabolism: Clinical and Experimental, Vol. 45, No. 4, 1996, p. 510-514.

Research output: Contribution to journalArticle

Tsukahara, H, Miura, M, Hori, C, Hiraoka, M, Nosaka, K, Hata, K, Konishi, Y & Sudo, M 1996, 'Urinary excretion of pyridinium cross-links of collagen in infancy', Metabolism: Clinical and Experimental, vol. 45, no. 4, pp. 510-514. https://doi.org/10.1016/S0026-0495(96)90228-0
Tsukahara, Hirokazu ; Miura, Masakazu ; Hori, Chikahide ; Hiraoka, Masahiro ; Nosaka, Kazuhiko ; Hata, Keishi ; Konishi, Yukuo ; Sudo, Masakatsu. / Urinary excretion of pyridinium cross-links of collagen in infancy. In: Metabolism: Clinical and Experimental. 1996 ; Vol. 45, No. 4. pp. 510-514.
@article{8984132c26174cfda5e1c25ec8d48933,
title = "Urinary excretion of pyridinium cross-links of collagen in infancy",
abstract = "This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.",
author = "Hirokazu Tsukahara and Masakazu Miura and Chikahide Hori and Masahiro Hiraoka and Kazuhiko Nosaka and Keishi Hata and Yukuo Konishi and Masakatsu Sudo",
year = "1996",
doi = "10.1016/S0026-0495(96)90228-0",
language = "English",
volume = "45",
pages = "510--514",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Urinary excretion of pyridinium cross-links of collagen in infancy

AU - Tsukahara, Hirokazu

AU - Miura, Masakazu

AU - Hori, Chikahide

AU - Hiraoka, Masahiro

AU - Nosaka, Kazuhiko

AU - Hata, Keishi

AU - Konishi, Yukuo

AU - Sudo, Masakatsu

PY - 1996

Y1 - 1996

N2 - This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.

AB - This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high- performance liquid chromatography (HPLC). β2-Microglobulin (β2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β2M, and the values obtained did not correlate with β2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.

UR - http://www.scopus.com/inward/record.url?scp=0029939223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029939223&partnerID=8YFLogxK

U2 - 10.1016/S0026-0495(96)90228-0

DO - 10.1016/S0026-0495(96)90228-0

M3 - Article

VL - 45

SP - 510

EP - 514

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 4

ER -