Urinary cross-linked N-terminal telopeptide of type I collagen levels of infants with osteogenesis imperfecta and healthy infants

Miho Yamashita, Kosei Hasegawa, Yousuke Higuchi, Takayuki Miyai, Ayumi Okada, Hiroyuki Tanaka, Hirokazu Tsukahara

Research output: Contribution to journalArticle

Abstract

The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p < 0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p < 0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.

Original languageEnglish
Pages (from-to)435-439
Number of pages5
JournalActa Medica Okayama
Volume70
Issue number6
Publication statusPublished - 2016

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Osteogenesis Imperfecta
collagen type I trimeric cross-linked peptide

Keywords

  • Bone mass
  • Bone resorption marker
  • Bone turnover

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Urinary cross-linked N-terminal telopeptide of type I collagen levels of infants with osteogenesis imperfecta and healthy infants. / Yamashita, Miho; Hasegawa, Kosei; Higuchi, Yousuke; Miyai, Takayuki; Okada, Ayumi; Tanaka, Hiroyuki; Tsukahara, Hirokazu.

In: Acta Medica Okayama, Vol. 70, No. 6, 2016, p. 435-439.

Research output: Contribution to journalArticle

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