Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes

Takahiro Terami, Jun Wada, Kentaro Inoue, Atsuko Nakatsuka, Daisuke Ogawa, Sanae Teshigawara, Kazutoshi Murakami, Akihiro Katayama, Jun Eguchi, Hirofumi Makino

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: Urinary angiotensinogen has been reported as a marker for the activation of intrarenal renin-angiotensin system (RAS) in various kidney diseases. To investigate the importance of urinary angiotensinogen in diabetic nephropathy, we compared the urinary levels of angiotensinogen, albumin, and α1-microglobulin. Materials and methods: Japanese patients with type 2 diabetes at various stages of nephropathy (n=85) were enrolled, and we measured albumin/creatinine ratio (ACR) and urinary excretion of angiotensinogen and α1-microglobulin. We also compared the clinical data of the patients treated with or without angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors (RAS inhibitors [+], n=51; RAS inhibitors [-], n=34). Results: Urinary angiotensinogen levels positively correlated with ACR (r =0.367, P=3.84×10-4) and urinary α1-microglobulin (r=0.734, P=1.32 × 10-15), while they negatively correlated with estimated glomerular filtration ratio (eGFR) (r=-0.350, P=1.02 × 10-3) and high-density lipoprotein cholesterol (r=-0.216, P=0.049). Multiple regression analysis was carried out to predict urinary angiotensinogen levels by employing eGFR, ACR, and urinary α1-microglobulin as independent variables; only urinary α1-microglobulin entered the regression equation at a significant level. Although ACR was higher in the RAS inhibitors (+) group, urinary α1-microglobulin and angiotensinogen did not show significant increase in the RAS inhibitors (+) group. Conclusion: Urinary angiotensinogen is well correlated with urinary α1-microglobulin and reflected the tubular injuries which may be associated with the intrarenal RAS activation in patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalInternational Journal of Nephrology and Renovascular Disease
Volume6
DOIs
Publication statusPublished - Oct 22 2013

Fingerprint

Angiotensinogen
Type 2 Diabetes Mellitus
Renin-Angiotensin System
Wounds and Injuries
Albumins
Creatinine
Angiotensin Receptor Antagonists
Kidney Diseases
Diabetic Nephropathies
Angiotensin-Converting Enzyme Inhibitors
HDL Cholesterol
Regression Analysis

Keywords

  • α1-microglobulin
  • Albumin
  • Angiotensinogen
  • Diabetic nephropathy
  • Renin-angiotensin system
  • Urinary biomarkers

ASJC Scopus subject areas

  • Nephrology

Cite this

Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes. / Terami, Takahiro; Wada, Jun; Inoue, Kentaro; Nakatsuka, Atsuko; Ogawa, Daisuke; Teshigawara, Sanae; Murakami, Kazutoshi; Katayama, Akihiro; Eguchi, Jun; Makino, Hirofumi.

In: International Journal of Nephrology and Renovascular Disease, Vol. 6, 22.10.2013, p. 233-240.

Research output: Contribution to journalArticle

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abstract = "Purpose: Urinary angiotensinogen has been reported as a marker for the activation of intrarenal renin-angiotensin system (RAS) in various kidney diseases. To investigate the importance of urinary angiotensinogen in diabetic nephropathy, we compared the urinary levels of angiotensinogen, albumin, and α1-microglobulin. Materials and methods: Japanese patients with type 2 diabetes at various stages of nephropathy (n=85) were enrolled, and we measured albumin/creatinine ratio (ACR) and urinary excretion of angiotensinogen and α1-microglobulin. We also compared the clinical data of the patients treated with or without angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors (RAS inhibitors [+], n=51; RAS inhibitors [-], n=34). Results: Urinary angiotensinogen levels positively correlated with ACR (r =0.367, P=3.84×10-4) and urinary α1-microglobulin (r=0.734, P=1.32 × 10-15), while they negatively correlated with estimated glomerular filtration ratio (eGFR) (r=-0.350, P=1.02 × 10-3) and high-density lipoprotein cholesterol (r=-0.216, P=0.049). Multiple regression analysis was carried out to predict urinary angiotensinogen levels by employing eGFR, ACR, and urinary α1-microglobulin as independent variables; only urinary α1-microglobulin entered the regression equation at a significant level. Although ACR was higher in the RAS inhibitors (+) group, urinary α1-microglobulin and angiotensinogen did not show significant increase in the RAS inhibitors (+) group. Conclusion: Urinary angiotensinogen is well correlated with urinary α1-microglobulin and reflected the tubular injuries which may be associated with the intrarenal RAS activation in patients with type 2 diabetes.",
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AU - Terami, Takahiro

AU - Wada, Jun

AU - Inoue, Kentaro

AU - Nakatsuka, Atsuko

AU - Ogawa, Daisuke

AU - Teshigawara, Sanae

AU - Murakami, Kazutoshi

AU - Katayama, Akihiro

AU - Eguchi, Jun

AU - Makino, Hirofumi

PY - 2013/10/22

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KW - Albumin

KW - Angiotensinogen

KW - Diabetic nephropathy

KW - Renin-angiotensin system

KW - Urinary biomarkers

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