Urinary α1 as an index of proximal tubular function in early infancy

Hirokazu Tsukahara; Masahiro Hiraoka; Masanori Kurivama; Masakazu Saito; Kiyoshi Morikawa; Mitsuhiko Kuroda; Toshiro Tominaga; Masakatsu Sudo

doi:10.1007/BF00864399

Urinary α₁ as an index of proximal tubular function in early infancy

Hirokazu Tsukahara, Masahiro Hiraoka, Masanori Kurivama, Masakazu Saito, Kiyoshi Morikawa, Mitsuhiko Kuroda, Toshiro Tominaga, Masakatsu Sudo

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Urinary α₁-microglobulin (U-A₁M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A₁M was high until day 14 and declined thereafter. It was significantly correlated with urinary β₂-microglobulin (U-B₂M) throughout the study, but not with serum A₁M on days 1 or 7. Similar to U-B₂M, U-A₁M in the clinically stable term infants with intrauterine growth retardation (n=4-7) was not elevated on days 1-7. In the sick infants who needed immediate resuscitatio at birth (n=4-8), U-A₁M as well as U-B₂M was high on days 1-7 and then decreased to normal levels, suggesting that U-A₁M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A₁M is a useful index of proximal tubular function in early infancy.

Original language	English
Pages (from-to)	199-201
Number of pages	3
Journal	Pediatric Nephrology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/BF00864399
Publication status	Published - Apr 1993
Externally published	Yes

Keywords

Early infancy
Renal proximal tubular function
Term infants
Urinary α-microglobulin
Urinary β-microglobulin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

Access to Document

10.1007/BF00864399

Cite this

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title = "Urinary α1 as an index of proximal tubular function in early infancy",

abstract = "Urinary α1-microglobulin (U-A1M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A1M was high until day 14 and declined thereafter. It was significantly correlated with urinary β2-microglobulin (U-B2M) throughout the study, but not with serum A1M on days 1 or 7. Similar to U-B2M, U-A1M in the clinically stable term infants with intrauterine growth retardation (n=4-7) was not elevated on days 1-7. In the sick infants who needed immediate resuscitatio at birth (n=4-8), U-A1M as well as U-B2M was high on days 1-7 and then decreased to normal levels, suggesting that U-A1M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A1M is a useful index of proximal tubular function in early infancy.",

keywords = "Early infancy, Renal proximal tubular function, Term infants, Urinary α-microglobulin, Urinary β-microglobulin",

author = "Hirokazu Tsukahara and Masahiro Hiraoka and Masanori Kurivama and Masakazu Saito and Kiyoshi Morikawa and Mitsuhiko Kuroda and Toshiro Tominaga and Masakatsu Sudo",

year = "1993",

month = apr,

doi = "10.1007/BF00864399",

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T1 - Urinary α1 as an index of proximal tubular function in early infancy

AU - Tsukahara, Hirokazu

AU - Hiraoka, Masahiro

AU - Kurivama, Masanori

AU - Saito, Masakazu

AU - Morikawa, Kiyoshi

AU - Kuroda, Mitsuhiko

AU - Tominaga, Toshiro

AU - Sudo, Masakatsu

PY - 1993/4

Y1 - 1993/4

N2 - Urinary α1-microglobulin (U-A1M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A1M was high until day 14 and declined thereafter. It was significantly correlated with urinary β2-microglobulin (U-B2M) throughout the study, but not with serum A1M on days 1 or 7. Similar to U-B2M, U-A1M in the clinically stable term infants with intrauterine growth retardation (n=4-7) was not elevated on days 1-7. In the sick infants who needed immediate resuscitatio at birth (n=4-8), U-A1M as well as U-B2M was high on days 1-7 and then decreased to normal levels, suggesting that U-A1M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A1M is a useful index of proximal tubular function in early infancy.

AB - Urinary α1-microglobulin (U-A1M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A1M was high until day 14 and declined thereafter. It was significantly correlated with urinary β2-microglobulin (U-B2M) throughout the study, but not with serum A1M on days 1 or 7. Similar to U-B2M, U-A1M in the clinically stable term infants with intrauterine growth retardation (n=4-7) was not elevated on days 1-7. In the sick infants who needed immediate resuscitatio at birth (n=4-8), U-A1M as well as U-B2M was high on days 1-7 and then decreased to normal levels, suggesting that U-A1M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A1M is a useful index of proximal tubular function in early infancy.

KW - Early infancy

KW - Renal proximal tubular function

KW - Term infants

KW - Urinary α-microglobulin

KW - Urinary β-microglobulin

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