Urinary α1 as an index of proximal tubular function in early infancy

Hirokazu Tsukahara, Masahiro Hiraoka, Masanori Kurivama, Masakazu Saito, Kiyoshi Morikawa, Mitsuhiko Kuroda, Toshiro Tominaga, Masakatsu Sudo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Urinary α1-microglobulin (U-A1M) was measured in healthy term infants on days 1, 4, 7, 14, 28, 90 and 180 of life. U-A1M was high until day 14 and declined thereafter. It was significantly correlated with urinary β2-microglobulin (U-B2M) throughout the study, but not with serum A1M on days 1 or 7. Similar to U-B2M, U-A1M in the clinically stable term infants with intrauterine growth retardation (n=4-7) was not elevated on days 1-7. In the sick infants who needed immediate resuscitatio at birth (n=4-8), U-A1M as well as U-B2M was high on days 1-7 and then decreased to normal levels, suggesting that U-A1M can be used as a sensitive marker of acute proximal tubular damage and its recovery. These observations indicate that U-A1M is a useful index of proximal tubular function in early infancy.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
JournalPediatric Nephrology
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 1993
Externally publishedYes

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Fetal Growth Retardation
Parturition
Serum

Keywords

  • Early infancy
  • Renal proximal tubular function
  • Term infants
  • Urinary α-microglobulin
  • Urinary β-microglobulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Tsukahara, H., Hiraoka, M., Kurivama, M., Saito, M., Morikawa, K., Kuroda, M., ... Sudo, M. (1993). Urinary α1 as an index of proximal tubular function in early infancy. Pediatric Nephrology, 7(2), 199-201. https://doi.org/10.1007/BF00864399

Urinary α1 as an index of proximal tubular function in early infancy. / Tsukahara, Hirokazu; Hiraoka, Masahiro; Kurivama, Masanori; Saito, Masakazu; Morikawa, Kiyoshi; Kuroda, Mitsuhiko; Tominaga, Toshiro; Sudo, Masakatsu.

In: Pediatric Nephrology, Vol. 7, No. 2, 04.1993, p. 199-201.

Research output: Contribution to journalArticle

Tsukahara, H, Hiraoka, M, Kurivama, M, Saito, M, Morikawa, K, Kuroda, M, Tominaga, T & Sudo, M 1993, 'Urinary α1 as an index of proximal tubular function in early infancy', Pediatric Nephrology, vol. 7, no. 2, pp. 199-201. https://doi.org/10.1007/BF00864399
Tsukahara, Hirokazu ; Hiraoka, Masahiro ; Kurivama, Masanori ; Saito, Masakazu ; Morikawa, Kiyoshi ; Kuroda, Mitsuhiko ; Tominaga, Toshiro ; Sudo, Masakatsu. / Urinary α1 as an index of proximal tubular function in early infancy. In: Pediatric Nephrology. 1993 ; Vol. 7, No. 2. pp. 199-201.
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