Upregulation of insulin-like growth factor receptor gene in experimental diabetic rat glomeruli

Hikaru Sugimoto, Kenichi Shikata, Hirofumi Makino, Kosuke Ota, Zensuke Ota

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2 Citations (Scopus)

Abstract

Renal hypertrophy is a characteristic and early manifestation of diabetes in human and experimental animals. We examined the precise distribution of insulin-like growth factor-I (IGF-I) receptor mRNA in the experimental diabetic rat kidney using a nonradioactive in situ hybridization technique. Expression of IGF-I receptor mRNA was rarely seen in the glomeruli of control rats. IGF-I receptor mRNA was detected after induction of diabetes in glomerular mesangial, visceral epithelial, and parietal epithelial cells. The number of IGF-I receptor mRNA-positive cells in a glomerulus increased significantly at 4 weeks as compared with the control rats. Overexpression of IGF-I receptor in glomerular cells may contribute to the glomerular hypertrophy in diabetic nephropathy.

Original languageEnglish
Pages (from-to)262-264
Number of pages3
JournalJournal of Diabetes and Its Complications
Volume9
Issue number4
DOIs
Publication statusPublished - Jan 1 1995

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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