Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases: A report of three cases

Hitoshi Sugiyama, Mie Maruyama, Hiroshi Morinaga, Tatsuyuki Inoue, Kei Ichi Takiue, Yoko Kikumoto, Masaru Kinomura, Ken Ei Sada, Shigeru Akagi, Shinji Kitamura, Yohei Maeshima, Hirofumi Makino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each case, the GBM contained microstructures, including microspheres and microtubular structures, accompanied by podocytic infolding into the GBM when examined by electron microscope. The size of the microstructures in the GBM ranged from 40 to 160 nm. Glomerular endothelial cells also seemed to be infolded in the GBM in a case with lupus nephritis. The response to glucocorticoid therapy was favorable in two cases. The cause of these morphological changes in the GBM might be associated with autoimmune disorders.

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalClinical and Experimental Nephrology
Volume12
Issue number6
DOIs
Publication statusPublished - Dec 1 2008

Keywords

  • Glomerular basement membrane
  • Microspheres
  • Microstructures
  • Microtubular structure
  • Podocytic infolding

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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