TY - JOUR
T1 - Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases
T2 - A report of three cases
AU - Sugiyama, Hitoshi
AU - Maruyama, Mie
AU - Morinaga, Hiroshi
AU - Inoue, Tatsuyuki
AU - Takiue, Kei Ichi
AU - Kikumoto, Yoko
AU - Kinomura, Masaru
AU - Sada, Kenei
AU - Akagi, Shigeru
AU - Kitamura, Shinji
AU - Maeshima, Yohei
AU - Makino, Hirofumi
PY - 2008/12
Y1 - 2008/12
N2 - Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each case, the GBM contained microstructures, including microspheres and microtubular structures, accompanied by podocytic infolding into the GBM when examined by electron microscope. The size of the microstructures in the GBM ranged from 40 to 160 nm. Glomerular endothelial cells also seemed to be infolded in the GBM in a case with lupus nephritis. The response to glucocorticoid therapy was favorable in two cases. The cause of these morphological changes in the GBM might be associated with autoimmune disorders.
AB - Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each case, the GBM contained microstructures, including microspheres and microtubular structures, accompanied by podocytic infolding into the GBM when examined by electron microscope. The size of the microstructures in the GBM ranged from 40 to 160 nm. Glomerular endothelial cells also seemed to be infolded in the GBM in a case with lupus nephritis. The response to glucocorticoid therapy was favorable in two cases. The cause of these morphological changes in the GBM might be associated with autoimmune disorders.
KW - Glomerular basement membrane
KW - Microspheres
KW - Microstructures
KW - Microtubular structure
KW - Podocytic infolding
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U2 - 10.1007/s10157-008-0098-6
DO - 10.1007/s10157-008-0098-6
M3 - Article
C2 - 18839060
AN - SCOPUS:56649099059
SN - 1342-1751
VL - 12
SP - 450
EP - 454
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 6
ER -