Abstract
Remarkable progress has been made in understanding the mechanism by which growth factors and oocytes can regulate the development and function of granulosa cells. Insufficiency of two oocyte-specific growth factors, growth differentiation factor-9 and bone morphogenetic protein (BMP)-15, cause female infertility. Expression of mRNA and/or protein for the BMP system components, including ligands, receptors and intracellular signal transduction factors, was demonstrated in cell components of growing preantral follicles, and biofunctional experiments have further revealed many important roles of the BMP system in regulation of reproductive function. In this review, recent advances in studies on biological actions of BMPs in ovarian folliculogenesis and in related endocrine tissues are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 131-142 |
| Number of pages | 12 |
| Journal | Reproductive Medicine and Biology |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2011 |
Fingerprint
Keywords
- Bone morphogenetic protein
- Folliculogenesis
- Ovary
- Reproduction and steroidogenesis
ASJC Scopus subject areas
- Reproductive Medicine
- Cell Biology
Cite this
Unique bioactivities of bone morphogenetic proteins in regulation of reproductive endocrine functions. / Otsuka, Fumio; Inagaki, Kenichi.
In: Reproductive Medicine and Biology, Vol. 10, No. 3, 09.2011, p. 131-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unique bioactivities of bone morphogenetic proteins in regulation of reproductive endocrine functions
AU - Otsuka, Fumio
AU - Inagaki, Kenichi
PY - 2011/9
Y1 - 2011/9
N2 - Remarkable progress has been made in understanding the mechanism by which growth factors and oocytes can regulate the development and function of granulosa cells. Insufficiency of two oocyte-specific growth factors, growth differentiation factor-9 and bone morphogenetic protein (BMP)-15, cause female infertility. Expression of mRNA and/or protein for the BMP system components, including ligands, receptors and intracellular signal transduction factors, was demonstrated in cell components of growing preantral follicles, and biofunctional experiments have further revealed many important roles of the BMP system in regulation of reproductive function. In this review, recent advances in studies on biological actions of BMPs in ovarian folliculogenesis and in related endocrine tissues are discussed.
AB - Remarkable progress has been made in understanding the mechanism by which growth factors and oocytes can regulate the development and function of granulosa cells. Insufficiency of two oocyte-specific growth factors, growth differentiation factor-9 and bone morphogenetic protein (BMP)-15, cause female infertility. Expression of mRNA and/or protein for the BMP system components, including ligands, receptors and intracellular signal transduction factors, was demonstrated in cell components of growing preantral follicles, and biofunctional experiments have further revealed many important roles of the BMP system in regulation of reproductive function. In this review, recent advances in studies on biological actions of BMPs in ovarian folliculogenesis and in related endocrine tissues are discussed.
KW - Bone morphogenetic protein
KW - Folliculogenesis
KW - Ovary
KW - Reproduction and steroidogenesis
UR - http://www.scopus.com/inward/record.url?scp=80054928917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054928917&partnerID=8YFLogxK
U2 - 10.1007/s12522-011-0082-9
DO - 10.1007/s12522-011-0082-9
M3 - Article
AN - SCOPUS:80054928917
VL - 10
SP - 131
EP - 142
JO - Reproductive Medicine and Biology
JF - Reproductive Medicine and Biology
SN - 1445-5781
IS - 3
ER -