Unique bioactivities of bone morphogenetic proteins in regulation of reproductive endocrine functions

Fumio Otsuka; Kenichi Inagaki

doi:10.1007/s12522-011-0082-9

Unique bioactivities of bone morphogenetic proteins in regulation of reproductive endocrine functions

Fumio Otsuka, Kenichi Inagaki

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Remarkable progress has been made in understanding the mechanism by which growth factors and oocytes can regulate the development and function of granulosa cells. Insufficiency of two oocyte-specific growth factors, growth differentiation factor-9 and bone morphogenetic protein (BMP)-15, cause female infertility. Expression of mRNA and/or protein for the BMP system components, including ligands, receptors and intracellular signal transduction factors, was demonstrated in cell components of growing preantral follicles, and biofunctional experiments have further revealed many important roles of the BMP system in regulation of reproductive function. In this review, recent advances in studies on biological actions of BMPs in ovarian folliculogenesis and in related endocrine tissues are discussed.

Original language	English
Pages (from-to)	131-142
Number of pages	12
Journal	Reproductive Medicine and Biology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s12522-011-0082-9
Publication status	Published - Sep 2011

Keywords

Bone morphogenetic protein
Folliculogenesis
Ovary
Reproduction and steroidogenesis

ASJC Scopus subject areas

Reproductive Medicine
Cell Biology

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abstract = "Remarkable progress has been made in understanding the mechanism by which growth factors and oocytes can regulate the development and function of granulosa cells. Insufficiency of two oocyte-specific growth factors, growth differentiation factor-9 and bone morphogenetic protein (BMP)-15, cause female infertility. Expression of mRNA and/or protein for the BMP system components, including ligands, receptors and intracellular signal transduction factors, was demonstrated in cell components of growing preantral follicles, and biofunctional experiments have further revealed many important roles of the BMP system in regulation of reproductive function. In this review, recent advances in studies on biological actions of BMPs in ovarian folliculogenesis and in related endocrine tissues are discussed.",

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AU - Inagaki, Kenichi

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AB - Remarkable progress has been made in understanding the mechanism by which growth factors and oocytes can regulate the development and function of granulosa cells. Insufficiency of two oocyte-specific growth factors, growth differentiation factor-9 and bone morphogenetic protein (BMP)-15, cause female infertility. Expression of mRNA and/or protein for the BMP system components, including ligands, receptors and intracellular signal transduction factors, was demonstrated in cell components of growing preantral follicles, and biofunctional experiments have further revealed many important roles of the BMP system in regulation of reproductive function. In this review, recent advances in studies on biological actions of BMPs in ovarian folliculogenesis and in related endocrine tissues are discussed.

KW - Bone morphogenetic protein

KW - Folliculogenesis

KW - Ovary

KW - Reproduction and steroidogenesis

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Unique bioactivities of bone morphogenetic proteins in regulation of reproductive endocrine functions

Abstract

Keywords

ASJC Scopus subject areas

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