Unique antimicrobial spectrum of ophiobolin K produced by Aspergillus ustus

Natthapat Sohsomboon; Hiroshi Kanzaki; Teruhiko Nitoda

doi:10.1080/09168451.2018.1429890

Unique antimicrobial spectrum of ophiobolin K produced by Aspergillus ustus

Natthapat Sohsomboon, Hiroshi Kanzaki, Teruhiko Nitoda

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A co-cultivation study of two fungal strains showed that Aspergillus ustus could inhibit Aspergillus repens growth. The bioactive compound responsible for the observed activity was purified and identified as a sesterterpene, ophiobolin K. Ophiobolin K exhibited marked inhibition against both fungi and bacteria, especially A. repens, A. glaucus and gram-positive bacteria including Bacillus subtilis, Staphylococcus aureus, and Micrococcus luteus.

Original language	English
Pages (from-to)	422-424
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	82
Issue number	3
DOIs	https://doi.org/10.1080/09168451.2018.1429890
Publication status	Published - 2018

Keywords

Antifungal activity
Co-cultivation
Sesterterpene

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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abstract = "A co-cultivation study of two fungal strains showed that Aspergillus ustus could inhibit Aspergillus repens growth. The bioactive compound responsible for the observed activity was purified and identified as a sesterterpene, ophiobolin K. Ophiobolin K exhibited marked inhibition against both fungi and bacteria, especially A. repens, A. glaucus and gram-positive bacteria including Bacillus subtilis, Staphylococcus aureus, and Micrococcus luteus.",

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