Unexpected correlation in the sensitivity of 19 herpes simplex virus strains to types I and II interferons

Y. Arao, Y. Ando, M. Narita, T. Kurata

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We compared the sensitivity of 19 herpes simplex virus (HSV) strains to type I (IFN-α and IFN-β) and type II (IFN-γ) human interferons in cultures of human retinal epithelial (K-1034) and lung (HEL) cells. Their sensitivities proved to be well correlated, even though type I and type II IFN have been reported to have different antiviral actions. The correlation was not because IFN-γ stimulated the formation of IFN-β, for an antibody that neutralized IFN-β did not reduce its inhibitory effects. Our results show that each HSV strain has a characteristic and similar sensitivity to type I and type II IFN and suggest some common pathway in the mechanism of their antiviral actions.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalJournal of Interferon and Cytokine Research
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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