Ultrastructure of mesangial type III collagen deposition in a patient with IgA nephropathy

Mie Kunitomi, Jun Wada, Nobuyuki Miyatake, Yoshiko Hayashi, Kosuke Ota, Hirofumi Makino

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a case of IgA nephropathy with focal and segmental deposition of type III collagen in mesangium, confirmed by immunohistochemical and electron microscopic methods. Tissue negative staining showed that focal and segmental fibrotic lesions in the mesangial area consisted of disarrayed or curled striated collagen fibers and striated membranous structures. Diabetes mellitus, hypertension, and advanced glomerular sclerosis were absent in this case, and mesangial cells surrounding the type III collagen showed vacuolar degeneration revealed by electron microscopy. Production of type III collagen may be the marker for phenotypic change of mesangial cells in immune-mediated glomerular diseases.

Original languageEnglish
Pages (from-to)146-152
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume32
Issue number1
Publication statusPublished - Jul 1998

Fingerprint

Collagen Type III
Immunoglobulin A
Mesangial Cells
Negative Staining
Sclerosis
Electron Microscopy
Diabetes Mellitus
Collagen
Electrons
Hypertension

Keywords

  • Collagen type III
  • IgA nephropathy
  • Interstitial collagen
  • Phenotypic change of mesangial cells
  • Striated membranous structure
  • Tissue negative staining

ASJC Scopus subject areas

  • Nephrology

Cite this

Ultrastructure of mesangial type III collagen deposition in a patient with IgA nephropathy. / Kunitomi, Mie; Wada, Jun; Miyatake, Nobuyuki; Hayashi, Yoshiko; Ota, Kosuke; Makino, Hirofumi.

In: American Journal of Kidney Diseases, Vol. 32, No. 1, 07.1998, p. 146-152.

Research output: Contribution to journalArticle

Kunitomi, Mie ; Wada, Jun ; Miyatake, Nobuyuki ; Hayashi, Yoshiko ; Ota, Kosuke ; Makino, Hirofumi. / Ultrastructure of mesangial type III collagen deposition in a patient with IgA nephropathy. In: American Journal of Kidney Diseases. 1998 ; Vol. 32, No. 1. pp. 146-152.
@article{f897e237a480474a9a5e86db7fdfc4c7,
title = "Ultrastructure of mesangial type III collagen deposition in a patient with IgA nephropathy",
abstract = "We report a case of IgA nephropathy with focal and segmental deposition of type III collagen in mesangium, confirmed by immunohistochemical and electron microscopic methods. Tissue negative staining showed that focal and segmental fibrotic lesions in the mesangial area consisted of disarrayed or curled striated collagen fibers and striated membranous structures. Diabetes mellitus, hypertension, and advanced glomerular sclerosis were absent in this case, and mesangial cells surrounding the type III collagen showed vacuolar degeneration revealed by electron microscopy. Production of type III collagen may be the marker for phenotypic change of mesangial cells in immune-mediated glomerular diseases.",
keywords = "Collagen type III, IgA nephropathy, Interstitial collagen, Phenotypic change of mesangial cells, Striated membranous structure, Tissue negative staining",
author = "Mie Kunitomi and Jun Wada and Nobuyuki Miyatake and Yoshiko Hayashi and Kosuke Ota and Hirofumi Makino",
year = "1998",
month = "7",
language = "English",
volume = "32",
pages = "146--152",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Ultrastructure of mesangial type III collagen deposition in a patient with IgA nephropathy

AU - Kunitomi, Mie

AU - Wada, Jun

AU - Miyatake, Nobuyuki

AU - Hayashi, Yoshiko

AU - Ota, Kosuke

AU - Makino, Hirofumi

PY - 1998/7

Y1 - 1998/7

N2 - We report a case of IgA nephropathy with focal and segmental deposition of type III collagen in mesangium, confirmed by immunohistochemical and electron microscopic methods. Tissue negative staining showed that focal and segmental fibrotic lesions in the mesangial area consisted of disarrayed or curled striated collagen fibers and striated membranous structures. Diabetes mellitus, hypertension, and advanced glomerular sclerosis were absent in this case, and mesangial cells surrounding the type III collagen showed vacuolar degeneration revealed by electron microscopy. Production of type III collagen may be the marker for phenotypic change of mesangial cells in immune-mediated glomerular diseases.

AB - We report a case of IgA nephropathy with focal and segmental deposition of type III collagen in mesangium, confirmed by immunohistochemical and electron microscopic methods. Tissue negative staining showed that focal and segmental fibrotic lesions in the mesangial area consisted of disarrayed or curled striated collagen fibers and striated membranous structures. Diabetes mellitus, hypertension, and advanced glomerular sclerosis were absent in this case, and mesangial cells surrounding the type III collagen showed vacuolar degeneration revealed by electron microscopy. Production of type III collagen may be the marker for phenotypic change of mesangial cells in immune-mediated glomerular diseases.

KW - Collagen type III

KW - IgA nephropathy

KW - Interstitial collagen

KW - Phenotypic change of mesangial cells

KW - Striated membranous structure

KW - Tissue negative staining

UR - http://www.scopus.com/inward/record.url?scp=0031835579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031835579&partnerID=8YFLogxK

M3 - Article

C2 - 9669436

AN - SCOPUS:0031835579

VL - 32

SP - 146

EP - 152

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 1

ER -