TY - JOUR
T1 - Ultrastructure of mesangial type III collagen deposition in a patient with IgA nephropathy
AU - Kunitomi, Mie
AU - Wada, Jun
AU - Miyatake, Nobuyuki
AU - Hayashi, Yoshiko
AU - Ota, Kosuke
AU - Makino, Hirofumi
PY - 1998/7
Y1 - 1998/7
N2 - We report a case of IgA nephropathy with focal and segmental deposition of type III collagen in mesangium, confirmed by immunohistochemical and electron microscopic methods. Tissue negative staining showed that focal and segmental fibrotic lesions in the mesangial area consisted of disarrayed or curled striated collagen fibers and striated membranous structures. Diabetes mellitus, hypertension, and advanced glomerular sclerosis were absent in this case, and mesangial cells surrounding the type III collagen showed vacuolar degeneration revealed by electron microscopy. Production of type III collagen may be the marker for phenotypic change of mesangial cells in immune-mediated glomerular diseases.
AB - We report a case of IgA nephropathy with focal and segmental deposition of type III collagen in mesangium, confirmed by immunohistochemical and electron microscopic methods. Tissue negative staining showed that focal and segmental fibrotic lesions in the mesangial area consisted of disarrayed or curled striated collagen fibers and striated membranous structures. Diabetes mellitus, hypertension, and advanced glomerular sclerosis were absent in this case, and mesangial cells surrounding the type III collagen showed vacuolar degeneration revealed by electron microscopy. Production of type III collagen may be the marker for phenotypic change of mesangial cells in immune-mediated glomerular diseases.
KW - Collagen type III
KW - IgA nephropathy
KW - Interstitial collagen
KW - Phenotypic change of mesangial cells
KW - Striated membranous structure
KW - Tissue negative staining
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U2 - 10.1053/ajkd.1998.v32.pm9669436
DO - 10.1053/ajkd.1998.v32.pm9669436
M3 - Article
C2 - 9669436
AN - SCOPUS:0031835579
VL - 32
SP - 146
EP - 152
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 1
ER -