Ultrastructural localization of tartrate-resistant acid phosphatase (TRAP) activity in metaphyseal osteoblasts of young rats was detected and compared with the localization of tartrate-sensitive acid phosphatase (TSAP). TRAP activity was detected in lysosomes and Golgi complex, such as Golgi lamellae, vacuoles and vesicles. TSAP, detected as β-glycerophosphatase, was also located in Golgi lamellae, vacuoles and vesicles, and in lysosomes. Based on the ultrastructural features of TRAP-positive structures and the similarity of the distribution patterns of TRAP and TSAP, it is suggested that TRAP co exists with TSAP, and is located in lysosomes and secretory granules in osteoblasts.
|Number of pages||5|
|Journal||Journal of Electron Microscopy|
|Publication status||Published - 1998|
- Bone formation
- Bone remodelling
- Tartrate-resistant acid phosphatase
ASJC Scopus subject areas