Ulcer Formation in Rat Stomach with Diethyldithiocarbamate

Keiki Ogino, Shinji Oka, Shinjiro Matsuura, Isao Sakaida, Shunji Yoshimura, Kazuya Matsuda, Yoshiyuki Sasaki, Kazunari Yamamoto, Yukinori Okazaki, Tadayoshi Takemoto, Toshikazu Yoshikawa

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesions after ischemia. To prove a participation of O2- in gastric mucosal lesion formation, diethyldithiocarbamate (DDC), an inhibitor of Cu,Zn-super-oxide dismutase (SOD), was injected into rats and its ulcerogenicity was examined. Subcutaneous injection of DDC was employed, because of high mortality after intraperitoneal injection of the drug. At 7 h after the injection of the drug, many ulcers appeared in the stomach, with suppression of SOD activities in the gastric mucosa, suggesting the participation of O2- in ulcer formation in the stomach.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
JournalJournal of Clinical Biochemistry and Nutrition
Volume3
Issue number3
DOIs
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Ditiocarb
Ulcer
Rats
Stomach
Superoxides
Pharmaceutical Preparations
Oxides
Subcutaneous Injections
Gastric Mucosa
Intraperitoneal Injections
Ischemia
Injections
Mortality
Superoxide Dismutase
Mucous Membrane

Keywords

  • diethyldithiocarbamate
  • rat stomach
  • ulcer

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Ogino, K., Oka, S., Matsuura, S., Sakaida, I., Yoshimura, S., Matsuda, K., ... Yoshikawa, T. (1987). Ulcer Formation in Rat Stomach with Diethyldithiocarbamate. Journal of Clinical Biochemistry and Nutrition, 3(3), 189-193. https://doi.org/10.3164/jcbn.3.189

Ulcer Formation in Rat Stomach with Diethyldithiocarbamate. / Ogino, Keiki; Oka, Shinji; Matsuura, Shinjiro; Sakaida, Isao; Yoshimura, Shunji; Matsuda, Kazuya; Sasaki, Yoshiyuki; Yamamoto, Kazunari; Okazaki, Yukinori; Takemoto, Tadayoshi; Yoshikawa, Toshikazu.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 3, No. 3, 1987, p. 189-193.

Research output: Contribution to journalArticle

Ogino, K, Oka, S, Matsuura, S, Sakaida, I, Yoshimura, S, Matsuda, K, Sasaki, Y, Yamamoto, K, Okazaki, Y, Takemoto, T & Yoshikawa, T 1987, 'Ulcer Formation in Rat Stomach with Diethyldithiocarbamate', Journal of Clinical Biochemistry and Nutrition, vol. 3, no. 3, pp. 189-193. https://doi.org/10.3164/jcbn.3.189
Ogino K, Oka S, Matsuura S, Sakaida I, Yoshimura S, Matsuda K et al. Ulcer Formation in Rat Stomach with Diethyldithiocarbamate. Journal of Clinical Biochemistry and Nutrition. 1987;3(3):189-193. https://doi.org/10.3164/jcbn.3.189
Ogino, Keiki ; Oka, Shinji ; Matsuura, Shinjiro ; Sakaida, Isao ; Yoshimura, Shunji ; Matsuda, Kazuya ; Sasaki, Yoshiyuki ; Yamamoto, Kazunari ; Okazaki, Yukinori ; Takemoto, Tadayoshi ; Yoshikawa, Toshikazu. / Ulcer Formation in Rat Stomach with Diethyldithiocarbamate. In: Journal of Clinical Biochemistry and Nutrition. 1987 ; Vol. 3, No. 3. pp. 189-193.
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