Ulcer Formation in Rat Stomach with Diethyldithiocarbamate

Keiki Ogino, Shinji Oka, Shinjiro Matsuura, Isao Sakaida, Shunji Yoshimura, Kazuya Matsuda, Yoshiyuki Sasaki, Kazunari Yamamoto, Yukinori Okazaki, Tadayoshi Takemoto, Toshikazu Yoshikawa

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29 Citations (Scopus)

Abstract

It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesions after ischemia. To prove a participation of O2- in gastric mucosal lesion formation, diethyldithiocarbamate (DDC), an inhibitor of Cu,Zn-super-oxide dismutase (SOD), was injected into rats and its ulcerogenicity was examined. Subcutaneous injection of DDC was employed, because of high mortality after intraperitoneal injection of the drug. At 7 h after the injection of the drug, many ulcers appeared in the stomach, with suppression of SOD activities in the gastric mucosa, suggesting the participation of O2- in ulcer formation in the stomach.

Original languageEnglish
Pages (from-to)189-193
Number of pages5
Journaljournal of clinical biochemistry and nutrition
Volume3
Issue number3
DOIs
Publication statusPublished - Jan 1 1987

Keywords

  • diethyldithiocarbamate
  • rat stomach
  • ulcer

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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    Ogino, K., Oka, S., Matsuura, S., Sakaida, I., Yoshimura, S., Matsuda, K., Sasaki, Y., Yamamoto, K., Okazaki, Y., Takemoto, T., & Yoshikawa, T. (1987). Ulcer Formation in Rat Stomach with Diethyldithiocarbamate. journal of clinical biochemistry and nutrition, 3(3), 189-193. https://doi.org/10.3164/jcbn.3.189