Two-year follow-up study of a patient with parkinson's disease and severe motor fluctuations treated by co-grafts of adrenal medulla and peripheral nerve into bilateral caudate nuclei: Case report

Isao Date, Shoji Asari, Takashi Ohmoto

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

WE PERFORMED CO-GRAFTS of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during “off” periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.

Original languageEnglish
Pages (from-to)515-519
Number of pages5
JournalNeurosurgery
Volume37
Issue number3
Publication statusPublished - 1995

Fingerprint

Adrenal Medulla
Caudate Nucleus
Peripheral Nerves
Parkinson Disease
Transplants
Benserazide
Levodopa
Carbon Monoxide
Transplantation
Therapeutics

Keywords

  • Adrenal medulla
  • Co-graft
  • Neural transplantation
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

@article{486240f5ff1646e9a43273312d84a720,
title = "Two-year follow-up study of a patient with parkinson's disease and severe motor fluctuations treated by co-grafts of adrenal medulla and peripheral nerve into bilateral caudate nuclei: Case report",
abstract = "WE PERFORMED CO-GRAFTS of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during “off” periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.",
keywords = "Adrenal medulla, Co-graft, Neural transplantation, Parkinson's disease",
author = "Isao Date and Shoji Asari and Takashi Ohmoto",
year = "1995",
language = "English",
volume = "37",
pages = "515--519",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Two-year follow-up study of a patient with parkinson's disease and severe motor fluctuations treated by co-grafts of adrenal medulla and peripheral nerve into bilateral caudate nuclei

T2 - Case report

AU - Date, Isao

AU - Asari, Shoji

AU - Ohmoto, Takashi

PY - 1995

Y1 - 1995

N2 - WE PERFORMED CO-GRAFTS of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during “off” periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.

AB - WE PERFORMED CO-GRAFTS of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during “off” periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.

KW - Adrenal medulla

KW - Co-graft

KW - Neural transplantation

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=0029083416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029083416&partnerID=8YFLogxK

M3 - Article

C2 - 7501119

AN - SCOPUS:0029083416

VL - 37

SP - 515

EP - 519

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 3

ER -