Two-year follow-up study of a patient with parkinson's disease and severe motor fluctuations treated by co-grafts of adrenal medulla and peripheral nerve into bilateral caudate nuclei: Case report

Isao Date, Shoji Asari, Takashi Ohmoto

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

WE PERFORMED CO-GRAFTS of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during “off” periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.

Original languageEnglish
Pages (from-to)515-519
Number of pages5
JournalNeurosurgery
Volume37
Issue number3
DOIs
Publication statusPublished - Sep 1995

Keywords

  • Adrenal medulla
  • Co-graft
  • Neural transplantation
  • Parkinson's disease

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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