Two Types of Polyp Shape Observed in the Stomach of Patients with Peutz-Jeghers Syndrome

Masaya Iwamuro, Tatsuya Toyokawa, Kazuhiro Matsueda, Shinichiro Hori, Masao Yoshioka, Yuki Moritou, Takehiro Tanaka, Motowo Mizuno, Hiroyuki Okada

Research output: Contribution to journalArticlepeer-review


The characteristics of gastric polyps in patients with Peutz-Jeghers (PJ) syndrome (PJS) have not been fully investigated. The objective of this study was to reveal the endoscopic and pathologic findings of gastric polyps in patients with PJS. We reviewed 11 patients with PJS treated at 6 institutions, and summarized the endoscopic and pathologic features of their gastric polyps. The polyps were mainly classified into 2 types: (i) solitary or sporadic polyps >5 mm, reddish in color with a sessile or semi-pedunculated morphology (n=9); and (ii) multiple sessile polyps ≤5 mm with the same color tone as the peripheral mucosa (n=9). Patients who underwent endoscopic mucosal resection for polyps >5 mm were diagnosed with PJ polyps (n=2), whereas those who underwent biopsy were diagnosed with hyperplastic polyps. Polyps ≤ 5 mm were pathologically diagnosed as fundic gland polyps or hyperplastic polyps. This study revealed that patients with PJS present with 2 types of polyps in the stomach. Endoscopic mucosal resection of polyps > 5 mm seems necessary for the pathologic diagnosis of PJ polyps.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalActa medica Okayama
Issue number4
Publication statusPublished - 2021


  • Peutz-Jeghers syndrome
  • esophagogastroduodenoscopy
  • gastric polyps

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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