Two new theonellapeptolide-related cyclic depsipeptides (1 and 2) have been isolated from an Okinawan marine sponge Theonella sp. and the structures were elucidated on the basis of the 2D NMR data, PSD analysis of MALDI- TOFMS, and chemical means. Compound 1 was a theonellapeptolide congener possessing a methylsulfinylacetyl group at the N-terminus, while 2 was another theonellapeptolide congener having an acetyl group at the N-terminus. Compounds 1 and 2 exhibited antimicrobial activity.
|Number of pages||10|
|Publication status||Published - Aug 20 1999|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry