Two theonellapeptolide congeners from marine sponge Theonella sp.

Masashi Tsuda, Kazutaka Shimbo, Takaaki Kubota, Yuzuru Mikami, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Two new theonellapeptolide-related cyclic depsipeptides (1 and 2) have been isolated from an Okinawan marine sponge Theonella sp. and the structures were elucidated on the basis of the 2D NMR data, PSD analysis of MALDI- TOFMS, and chemical means. Compound 1 was a theonellapeptolide congener possessing a methylsulfinylacetyl group at the N-terminus, while 2 was another theonellapeptolide congener having an acetyl group at the N-terminus. Compounds 1 and 2 exhibited antimicrobial activity.

Original languageEnglish
Pages (from-to)10305-10314
Number of pages10
JournalTetrahedron
Volume55
Issue number34
DOIs
Publication statusPublished - Aug 20 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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