Two sublines of a lymphoblastoid cell line associated with Marek's disease virus

M. Yamada, H. Matsuda, S. Nii

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From MDCC-MSB1, the original Marek's disease virus-associated lymphoblastoid cell line, two sublines named MDCC-MSB1-33C and MDCC-MSB1-41C were differentiated. The MDCC-MSB1-33C cell line grew well at 33°, but grew poorly and finally stopped growing at 41° . On the other hand, the MDCC-MSB1-41C cell line grew actively at 41°, but at 33°, continuous cultivation was difficult to achieve. MDCC-MSB1-33C grew suspended in the liquid medium, as did the original producer MDCC-MSB1 cell line, while MDCC-MSB1-41C grew attached to the substrate. Moreover, in soft agar, MDCC-MSB1-33C formed loose colonies, but MDCC-MSB1-41C formed packed colonies. Neither Marek's disease viral antigens nor herpes-type particles could be detected in either subline, although a Marek's disease tumor-associated surface antigen was found on the surface of both.

Original languageEnglish
Pages (from-to)502-508
Number of pages7
JournalGann, The Japanese Journal of Cancer Research
Issue number4
Publication statusPublished - Jan 1 1983


ASJC Scopus subject areas

  • Cancer Research

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