Two Relapsed Stage III Childhood Anaplastic Large Cell Lymphoma Patients with NPM-ALK Fusion in Bone Marrow from Initial Diagnosis

Yui Kanazawa, Yuka Yamashita, Mitsuhiro Fujiwara, Michiko Muraoka, Kana Washio, Kiichiro Kanamitsu, Hisashi Ishida, Takae Nakano, Miho Yamada, Keizo Horibe, Takehiro Tanaka, Tadashi Yoshino, Akira Shimada

Research output: Contribution to journalArticlepeer-review

Abstract

Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10–30 of cases of non-Hod-gkin lymphoma, and the ALCL99 study reported 60–75 disease-free survival; however, a relatively high relapse rate was observed (25–30 ). We report 2 patients with Stage III ALCL who relapsed 6–18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nuc-leophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be rela-tively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diag-nostic bone marrow sample

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalActa medica Okayama
Volume70
Issue number6
DOIs
Publication statusPublished - 2016

Keywords

  • ALCL
  • NPM-ALK fusion
  • lymphoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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