TY - JOUR
T1 - Two New Flavonoids and Other Constituents in Licorice Root Their Relative Astringency and Radical Scavenging Effects
AU - Hatano, Tsutomu
AU - Kagawa, Harumi
AU - Yasuhara, Taeko
AU - Okuda, Takuo
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1988
Y1 - 1988
N2 - Four compounds, including two new flavonoids, were isolated from Si-pei licorice (licorice from the north-western region of China). The structures of the two new flavonoids, named glycyrrhisoflavanone and glycyrrhisoflavone, were (S)-7,8#x0027;-dihydroxy-2#x0027;,2#x0027;-dimethyl-5-methoxy-[3,6#x0027;-bi-2H-l-benzopyran]-4(3H)-one (6) and 3-[3,4-dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-4H-l-benzopyran-4-one (9). Glycyrrhisoflavone was found to be one of the tannic substances by the measurement of the binding activity to hemoglobin (relative astringency). Licochalcone B (1) was isolated from the fraction which showed the highest binding activity to hemoglobin among the fractions obtained by centrifugal partition chromatography of the extract of Sinkiang licorice (licorice from Sinkiang in China). Licochalcone B also showed the highest activity as a radical scavenger in the experiment using 1, l-diphenyl-2-picrylhydrazyl radical, among ten tested compounds obtained from several licorices. The order of the radical scavenging effects was the same as the order of the inhibitory effects on the 5-lipoxygenase-dependent peroxidation in arachidonate metabolism [licochalcone B (1)> licochalcone A (3)»isoliquiritigenin (14) > liquiritigenin (13)].
AB - Four compounds, including two new flavonoids, were isolated from Si-pei licorice (licorice from the north-western region of China). The structures of the two new flavonoids, named glycyrrhisoflavanone and glycyrrhisoflavone, were (S)-7,8#x0027;-dihydroxy-2#x0027;,2#x0027;-dimethyl-5-methoxy-[3,6#x0027;-bi-2H-l-benzopyran]-4(3H)-one (6) and 3-[3,4-dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-4H-l-benzopyran-4-one (9). Glycyrrhisoflavone was found to be one of the tannic substances by the measurement of the binding activity to hemoglobin (relative astringency). Licochalcone B (1) was isolated from the fraction which showed the highest binding activity to hemoglobin among the fractions obtained by centrifugal partition chromatography of the extract of Sinkiang licorice (licorice from Sinkiang in China). Licochalcone B also showed the highest activity as a radical scavenger in the experiment using 1, l-diphenyl-2-picrylhydrazyl radical, among ten tested compounds obtained from several licorices. The order of the radical scavenging effects was the same as the order of the inhibitory effects on the 5-lipoxygenase-dependent peroxidation in arachidonate metabolism [licochalcone B (1)> licochalcone A (3)»isoliquiritigenin (14) > liquiritigenin (13)].
KW - GlycyrrhizaLeguminosae
KW - centrifugal partition chromatography
KW - glycyrrhisoflavanone
KW - glycyrrhisoflavone
KW - isoflavonoid licochalcone B
KW - licorice
KW - radical scavenger
KW - tannin
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U2 - 10.1248/cpb.36.2090
DO - 10.1248/cpb.36.2090
M3 - Article
C2 - 3240445
AN - SCOPUS:0023734093
VL - 36
SP - 2090
EP - 2097
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 6
ER -