Two new 11(15→1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis

Man Li Zhang, Jing Zhang, Mei Dong, Shu Hua Feng, Chang Hong Huo, Françoise Sauriol, Qing Wen Shi, Yu Cheng Gu, Hiromasa Kiyota, Bin Cong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two 11(15→1)abeotaxanes having a tetrahydrofuran ring along the carbon atoms C-2, C-3, C-4, C-20 were identified for the first time from the needles of the Canadian yew, Taxus canadensis. The compounds could be identified as 4α,10β,13α-triacetoxy-15-benzoyloxy-2α, 20β-epoxy-11(15→1)abeotax-11-ene-5α,7β,9α-triol (1) and 4α,7β,9α,10β,15-pentaacetoxy-2α,20β-epoxy- 11(15→1)abeotax-11-ene-5α,13α-diol (2) on the basis of 1D-, 2D-NMR evidence and high-resolution FABMS analysis. Compound 1 showed weak growth inhibitory activities against T-98 and MM1-CB cells in vitro.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume64
Issue number1-2
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Taxus
Needles
Carbon
Nuclear magnetic resonance
Atoms
Growth
lysine(6)-glutaryl-2-(hydroxymethyl)anthraquinone LHRH
tetrahydrofuran
In Vitro Techniques

Keywords

  • 11(15→1)Abeotaxanes
  • Cell growth inhibition
  • Structure elucidation
  • Taxus canadensis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zhang, M. L., Zhang, J., Dong, M., Feng, S. H., Huo, C. H., Sauriol, F., ... Cong, B. (2009). Two new 11(15→1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 64(1-2), 43-48.

Two new 11(15→1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis. / Zhang, Man Li; Zhang, Jing; Dong, Mei; Feng, Shu Hua; Huo, Chang Hong; Sauriol, Françoise; Shi, Qing Wen; Gu, Yu Cheng; Kiyota, Hiromasa; Cong, Bin.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 64, No. 1-2, 2009, p. 43-48.

Research output: Contribution to journalArticle

Zhang, ML, Zhang, J, Dong, M, Feng, SH, Huo, CH, Sauriol, F, Shi, QW, Gu, YC, Kiyota, H & Cong, B 2009, 'Two new 11(15→1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis', Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 64, no. 1-2, pp. 43-48.
Zhang, Man Li ; Zhang, Jing ; Dong, Mei ; Feng, Shu Hua ; Huo, Chang Hong ; Sauriol, Françoise ; Shi, Qing Wen ; Gu, Yu Cheng ; Kiyota, Hiromasa ; Cong, Bin. / Two new 11(15→1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis. In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2009 ; Vol. 64, No. 1-2. pp. 43-48.
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