Two-Component Signaling in the Virulence of Staphylococcus aureus: A Silkworm Larvae-Pathogenic Agent Infection Model of Virulence

Kenji Kurokawa, Chikara Kaito, Kazuhisa Sekimizu

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Abstract

Staphylococcus aureus is a pathogenic bacterium that causes abscesses, pneumonia, endocarditis, and food poisoning. S. aureus is also one of the resident flora of the endotherm and colonizes the host by skillfully evading its defense mechanism. Identification of attenuated mutants of S. aureus in an animal infection model is useful for investigating its adaptability and pathogenesis. This chapter describes a staphylococcal two-component SA0614-SA0615 system, which was identified using a silkworm larvae infection model.

Original languageEnglish
Title of host publicationTwo Component Signaling Systems, Part A
PublisherAcademic Press Inc.
Pages233-244
Number of pages12
DOIs
Publication statusPublished - Jan 1 2007
Externally publishedYes

Publication series

NameMethods in Enzymology
Volume422
ISSN (Print)0076-6879

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Kurokawa, K., Kaito, C., & Sekimizu, K. (2007). Two-Component Signaling in the Virulence of Staphylococcus aureus: A Silkworm Larvae-Pathogenic Agent Infection Model of Virulence. In Two Component Signaling Systems, Part A (pp. 233-244). (Methods in Enzymology; Vol. 422). Academic Press Inc.. https://doi.org/10.1016/S0076-6879(06)22011-1