Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80

Shunya Fujiwara, Yasuhiro Manabe, Ryuta Morihara, Taijun Yunoki, Syoichiro Kono, Hisashi Narai, Koji Abe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonance imaging showed longitudinal high-intensity signals on a T2-weighted image. The patients received high-dose methylprednisolone. Their serum was positive for anti-AQP4 antibody (cell-based assay) during the clinical course. They were diagnosed with NMOSD and treated with immunoadsorption, plasmapheresis, and followed up with daily prednisolone. Very-late-onset NMOSD in patients over the age of 80 has only rarely been reported. The present cases suggest that NMOSD should be considered for elderly patients presenting with transverse myelitis. Early diagnosis and treatment are important.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalCase Reports in Neurology
Volume12
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • Anti-aquaporin-4 antibody
  • Neuromyelitis optica
  • Transverse myelopathy
  • Very late onset

ASJC Scopus subject areas

  • Clinical Neurology

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