Two Cases of Probable Neuro-Behcet's Disease with Longitudinally Extensive Transverse Myelitis

Shunya Fujiwara; Yasuhiro Manabe; Yumiko Nakano; Yosio Omote; Taijun Yunoki; Syoichiro Kono; Hisashi Narai; Koji Abe

doi:10.1159/000512323

Two Cases of Probable Neuro-Behcet's Disease with Longitudinally Extensive Transverse Myelitis

Shunya Fujiwara, Yasuhiro Manabe, Yumiko Nakano, Yosio Omote, Taijun Yunoki, Syoichiro Kono, Hisashi Narai, Koji Abe

Research output: Contribution to journal › Article › peer-review

Abstract

We report 2 cases of probable neuro-Behcet's disease (NBD) with longitudinally extensive transverse myelitis (LETM). In both cases, the patients presented paraplegia, as well as sensory, bladder, and rectal disturbances. Magnetic resonance imaging (MRI) of patient 1 showed continuous high signal intensity extending from the midbrain to the entire spinal cord in the central part of the cord on T2-weighted imaging (T2WI). Spinal MRI of patient 2 revealed high signal intensity extending from Th2 to Th10 in the central part of the cord on T2WI. Both patients received high-dose methylprednisolone. A continuous lesion from the midbrain to the entire spinal cord as in patient 1 has not been previously reported. Patient 2 dramatically improved by infliximab therapy. The present cases suggest that NBD should be considered as a differential diagnosis in patients with LETM.

Original language	English
Pages (from-to)	78-83
Number of pages	6
Journal	Case Reports in Neurology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1159/000512323
Publication status	Published - Jan 2021

Keywords

Long spinal cord lesion
Myelitis
Neuro-Behcet's disease

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1159/000512323

Cite this

@article{6c367daaf182458a9eb403f7062913f5,

title = "Two Cases of Probable Neuro-Behcet's Disease with Longitudinally Extensive Transverse Myelitis",

abstract = "We report 2 cases of probable neuro-Behcet's disease (NBD) with longitudinally extensive transverse myelitis (LETM). In both cases, the patients presented paraplegia, as well as sensory, bladder, and rectal disturbances. Magnetic resonance imaging (MRI) of patient 1 showed continuous high signal intensity extending from the midbrain to the entire spinal cord in the central part of the cord on T2-weighted imaging (T2WI). Spinal MRI of patient 2 revealed high signal intensity extending from Th2 to Th10 in the central part of the cord on T2WI. Both patients received high-dose methylprednisolone. A continuous lesion from the midbrain to the entire spinal cord as in patient 1 has not been previously reported. Patient 2 dramatically improved by infliximab therapy. The present cases suggest that NBD should be considered as a differential diagnosis in patients with LETM. ",

keywords = "Long spinal cord lesion, Myelitis, Neuro-Behcet's disease",

author = "Shunya Fujiwara and Yasuhiro Manabe and Yumiko Nakano and Yosio Omote and Taijun Yunoki and Syoichiro Kono and Hisashi Narai and Koji Abe",

year = "2021",

month = jan,

doi = "10.1159/000512323",

language = "English",

volume = "13",

pages = "78--83",

journal = "Case Reports in Neurology",

issn = "1662-680X",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Two Cases of Probable Neuro-Behcet's Disease with Longitudinally Extensive Transverse Myelitis

AU - Fujiwara, Shunya

AU - Manabe, Yasuhiro

AU - Nakano, Yumiko

AU - Omote, Yosio

AU - Yunoki, Taijun

AU - Kono, Syoichiro

AU - Narai, Hisashi

AU - Abe, Koji

PY - 2021/1

Y1 - 2021/1

N2 - We report 2 cases of probable neuro-Behcet's disease (NBD) with longitudinally extensive transverse myelitis (LETM). In both cases, the patients presented paraplegia, as well as sensory, bladder, and rectal disturbances. Magnetic resonance imaging (MRI) of patient 1 showed continuous high signal intensity extending from the midbrain to the entire spinal cord in the central part of the cord on T2-weighted imaging (T2WI). Spinal MRI of patient 2 revealed high signal intensity extending from Th2 to Th10 in the central part of the cord on T2WI. Both patients received high-dose methylprednisolone. A continuous lesion from the midbrain to the entire spinal cord as in patient 1 has not been previously reported. Patient 2 dramatically improved by infliximab therapy. The present cases suggest that NBD should be considered as a differential diagnosis in patients with LETM.

AB - We report 2 cases of probable neuro-Behcet's disease (NBD) with longitudinally extensive transverse myelitis (LETM). In both cases, the patients presented paraplegia, as well as sensory, bladder, and rectal disturbances. Magnetic resonance imaging (MRI) of patient 1 showed continuous high signal intensity extending from the midbrain to the entire spinal cord in the central part of the cord on T2-weighted imaging (T2WI). Spinal MRI of patient 2 revealed high signal intensity extending from Th2 to Th10 in the central part of the cord on T2WI. Both patients received high-dose methylprednisolone. A continuous lesion from the midbrain to the entire spinal cord as in patient 1 has not been previously reported. Patient 2 dramatically improved by infliximab therapy. The present cases suggest that NBD should be considered as a differential diagnosis in patients with LETM.

KW - Long spinal cord lesion

KW - Myelitis

KW - Neuro-Behcet's disease

UR - http://www.scopus.com/inward/record.url?scp=85100726138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85100726138&partnerID=8YFLogxK

U2 - 10.1159/000512323

DO - 10.1159/000512323

M3 - Article

AN - SCOPUS:85100726138

SN - 1662-680X

VL - 13

SP - 78

EP - 83

JO - Case Reports in Neurology

JF - Case Reports in Neurology

IS - 1

ER -

Two Cases of Probable Neuro-Behcet's Disease with Longitudinally Extensive Transverse Myelitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this