Two Cases of Probable Neuro-Behcet's Disease with Longitudinally Extensive Transverse Myelitis

Shunya Fujiwara, Yasuhiro Manabe, Yumiko Nakano, Yoshio Omote, Taijun Yunoki, Syoichiro Kono, Hisashi Narai, Koji Abe

Research output: Contribution to journalArticlepeer-review

Abstract

We report 2 cases of probable neuro-Behcet's disease (NBD) with longitudinally extensive transverse myelitis (LETM). In both cases, the patients presented paraplegia, as well as sensory, bladder, and rectal disturbances. Magnetic resonance imaging (MRI) of patient 1 showed continuous high signal intensity extending from the midbrain to the entire spinal cord in the central part of the cord on T2-weighted imaging (T2WI). Spinal MRI of patient 2 revealed high signal intensity extending from Th2 to Th10 in the central part of the cord on T2WI. Both patients received high-dose methylprednisolone. A continuous lesion from the midbrain to the entire spinal cord as in patient 1 has not been previously reported. Patient 2 dramatically improved by infliximab therapy. The present cases suggest that NBD should be considered as a differential diagnosis in patients with LETM.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalCase Reports in Neurology
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Long spinal cord lesion
  • Myelitis
  • Neuro-Behcet's disease

ASJC Scopus subject areas

  • Clinical Neurology

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