Case 1 was a 79-year-old Japanese female who noticed a dome-shaped tumor that had developed rapidly on the right cheek. She had a metastatic submental lymph node. Case 2 was a 66-year-old Japanese female who noticed a nodule that was enlarging progressively on the left cheek. Histopathologically, malignant lymphoma was suspected. However, immunohistologically, positivity for cytokeratin 20 revealed Merkel cell carcinoma. Radiation therapy was successful, with no other therapy administered.
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