Two cases of Japanese CADASIL with corpus callosum lesion

Kaori Iwatsuki, Tetsuro Murakami, Yasuhiro Manabe, Hisashi Narai, Hitoshi Warita, Takeshi Hayashi, Koji Abe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a rare hereditary stroke disease. In the present study, a Japanese CADASIL family was first reported with missense mutation of Arg141Cys of Notch3 and a unique lesion of corpus callosum. Upon neuropsychological examination, our case 1 showed only right-handed constructional apraxia associated with corpus callosum lesion. No other callosal disconnection signs were present. Sagittal T2 weighted image of case 1 showed multiple small lesions along with the pericallosal branches from the truncus to the posterior part of the splenium in the corpus callosum. Although detailed mapping of the corpus callosum for functional fractionation in humans remains incomplete, the constructional apraxia on the right may be related to callosal dysfunction from the truncus to the posterior part of the splenium in the corpus callosum.-CADASIL; corpus callosum; constructional apraxia

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalTohoku Journal of Experimental Medicine
Volume195
Issue number2
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Iwatsuki, K., Murakami, T., Manabe, Y., Narai, H., Warita, H., Hayashi, T., & Abe, K. (2001). Two cases of Japanese CADASIL with corpus callosum lesion. Tohoku Journal of Experimental Medicine, 195(2), 135-140. https://doi.org/10.1620/tjem.195.135