Two cases of histiocytic necrotizlng lymphadenitis (kikuchi-fujimoto's disease) following diffuse large B-cell lymphoma

Tadashi Yoshino, Tomohiko Mannami, Koichi Ichimura, Katsuto Takenaka, Soichiro Nose, Ichiro Yamadori, Tadaatsu Akagi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Histiocytic necrotizing lymphadenitis (HNL) is often mistaken for malignant lymphoma clinically and is also sometimes difficult to differentiate from lymphoma even histopathologically. In this report, we describe the first 2 reported cases of HNL following non-Hodgkin's lymphomas. The patients were 27- and 30-year-old women who developed cervical and axillary lymph node swellings, respectively, in the course of remission of diffuse large B-cell lymphoma. The affected lymph nodes showed the typical histology of HNL: irregular-shaped 'necrotic' foci with histiocytes engulfing apoptotic bodies intermingled with large-sized blastic lymphocytes. These findings mimicked the partial involvement of large-cell lymphoma. However, the blastic cells were almost exclusively T cells, and numerous apoptotic bodies were present, which excluded the possibility of recurrence of diffuse large B-cell lymphoma. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)1328-1331
Number of pages4
JournalHuman Pathology
Volume31
Issue number10
DOIs
Publication statusPublished - 2000

Fingerprint

Histiocytic Necrotizing Lymphadenitis
Lymphadenitis
Lymphoma, Large B-Cell, Diffuse
Lymphoma
Lymph Nodes
Histiocytes
Non-Hodgkin's Lymphoma
Histology
Lymphocytes
T-Lymphocytes
Recurrence
Extracellular Vesicles

Keywords

  • Differential diagnosis
  • Diffuse large B-cell lymphoma
  • Histiocytic necrotizing lymphadenitis
  • Remission

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Two cases of histiocytic necrotizlng lymphadenitis (kikuchi-fujimoto's disease) following diffuse large B-cell lymphoma. / Yoshino, Tadashi; Mannami, Tomohiko; Ichimura, Koichi; Takenaka, Katsuto; Nose, Soichiro; Yamadori, Ichiro; Akagi, Tadaatsu.

In: Human Pathology, Vol. 31, No. 10, 2000, p. 1328-1331.

Research output: Contribution to journalArticle

Yoshino, Tadashi ; Mannami, Tomohiko ; Ichimura, Koichi ; Takenaka, Katsuto ; Nose, Soichiro ; Yamadori, Ichiro ; Akagi, Tadaatsu. / Two cases of histiocytic necrotizlng lymphadenitis (kikuchi-fujimoto's disease) following diffuse large B-cell lymphoma. In: Human Pathology. 2000 ; Vol. 31, No. 10. pp. 1328-1331.
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AU - Takenaka, Katsuto

AU - Nose, Soichiro

AU - Yamadori, Ichiro

AU - Akagi, Tadaatsu

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N2 - Histiocytic necrotizing lymphadenitis (HNL) is often mistaken for malignant lymphoma clinically and is also sometimes difficult to differentiate from lymphoma even histopathologically. In this report, we describe the first 2 reported cases of HNL following non-Hodgkin's lymphomas. The patients were 27- and 30-year-old women who developed cervical and axillary lymph node swellings, respectively, in the course of remission of diffuse large B-cell lymphoma. The affected lymph nodes showed the typical histology of HNL: irregular-shaped 'necrotic' foci with histiocytes engulfing apoptotic bodies intermingled with large-sized blastic lymphocytes. These findings mimicked the partial involvement of large-cell lymphoma. However, the blastic cells were almost exclusively T cells, and numerous apoptotic bodies were present, which excluded the possibility of recurrence of diffuse large B-cell lymphoma. Copyright (C) 2000 by W.B. Saunders Company.

AB - Histiocytic necrotizing lymphadenitis (HNL) is often mistaken for malignant lymphoma clinically and is also sometimes difficult to differentiate from lymphoma even histopathologically. In this report, we describe the first 2 reported cases of HNL following non-Hodgkin's lymphomas. The patients were 27- and 30-year-old women who developed cervical and axillary lymph node swellings, respectively, in the course of remission of diffuse large B-cell lymphoma. The affected lymph nodes showed the typical histology of HNL: irregular-shaped 'necrotic' foci with histiocytes engulfing apoptotic bodies intermingled with large-sized blastic lymphocytes. These findings mimicked the partial involvement of large-cell lymphoma. However, the blastic cells were almost exclusively T cells, and numerous apoptotic bodies were present, which excluded the possibility of recurrence of diffuse large B-cell lymphoma. Copyright (C) 2000 by W.B. Saunders Company.

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