Two cases of giant metastatic cervical lymphnode from oral cancer responding to concurrent chemoradiotherapy with S-1

Koji Kishimoto, Shoko Yoshida, Tatsuo Ono, Yasuto Yoshihama, Akiyoshi Nishiyama, Akira Sasaki

Research output: Contribution to journalArticle

Abstract

We report two cases of giant metastatic cervical lymphnode from oral squamous cell carcinoma, successfully treated with concurrent chemoradiotherapy with S-1. Case 1 was a 80-year-old male who had an ipsilateral occult neck metastasis(52x46 mm mass)at level IV after surgery of the left tongue carcinoma(T2N0M0). Radiotherapy(2.0 Gy/day; 5 days/week)was given at a total dose of 66 Gy. Two courses of oral administration of S-1(61 mg/m2/day)for 2 weeks followed by 1-week rest period as one course was repeated with the concurrent radiotherapy. After the radiotherapy, the oral administration of S-1 alone was continued for 1 year under the same regimen. Case 2 was a 51-year-old male who had left tongue carcinoma(T4bN2cM0)with ipsilateral cervical lymphnode metastasis(88x44 mm mass). The same chemoradiotherapy(1.8 Gy/day; 5 days/week; a total dose of 63 Gy; S-1 53 mg/m2/day)was carried out as in case 1. These giant metastatic lymphnodes of case 1 and 2 disappeared by 3 and 6 months after radiotherapy, respectively, and achieved a complete response. This therapy may be effective not only for primary lesion of oral cancer, but also metastatic regional lymphnodes in some cases.

Original languageEnglish
Pages (from-to)1727-1730
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume35
Issue number10
Publication statusPublished - Oct 2008

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Mouth Neoplasms
Chemoradiotherapy
Radiotherapy
Tongue
Oral Administration
Neoplasm Metastasis
Carcinoma
Squamous Cell Carcinoma
Neck
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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Two cases of giant metastatic cervical lymphnode from oral cancer responding to concurrent chemoradiotherapy with S-1. / Kishimoto, Koji; Yoshida, Shoko; Ono, Tatsuo; Yoshihama, Yasuto; Nishiyama, Akiyoshi; Sasaki, Akira.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 35, No. 10, 10.2008, p. 1727-1730.

Research output: Contribution to journalArticle

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AU - Nishiyama, Akiyoshi

AU - Sasaki, Akira

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