Two cases of advanced and metastatic breast cancers treated by docetaxel in combination with intra-arterial infusion of adriamycin

Hiroyoshi Doihara, S. Yoshitomi, M. Hino, A. Teramoto, Y. Ishibe, Y. Ogasawara, I. Nagahiro, Y. Sano, N. Shimizu

Research output: Contribution to journalArticle

Abstract

Two cases of advanced and metastatic breast cancers were treated by docetaxel (TXT) in combination with intra-arterial infusion of adriamycin (ADM). Patients received 60 mg/body TXT i.v. and 30 mg/body ADM ia (AT therapy) bi-weekly. Clinical responses were observed in these two patients and the durations of responses were over 20 weeks. Critical toxicities of grade 2 leukopenia and alopecia were observed but grade 4 severe toxicities were not. Thus AT therapy can be easily and safely performed with outpatients. This therapy can improve the response rate and time to progression; therefore phase I or phase I/II clinical trials of AT therapy in Japan are recommended.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume28
Issue number2
Publication statusPublished - Feb 2001

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docetaxel
Intra Arterial Infusions
Doxorubicin
Breast Neoplasms
Phase II Clinical Trials
Clinical Trials, Phase I
Alopecia
Leukopenia
Therapeutics
Japan
Outpatients

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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Two cases of advanced and metastatic breast cancers treated by docetaxel in combination with intra-arterial infusion of adriamycin. / Doihara, Hiroyoshi; Yoshitomi, S.; Hino, M.; Teramoto, A.; Ishibe, Y.; Ogasawara, Y.; Nagahiro, I.; Sano, Y.; Shimizu, N.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 28, No. 2, 02.2001, p. 229-233.

Research output: Contribution to journalArticle

Doihara, H, Yoshitomi, S, Hino, M, Teramoto, A, Ishibe, Y, Ogasawara, Y, Nagahiro, I, Sano, Y & Shimizu, N 2001, 'Two cases of advanced and metastatic breast cancers treated by docetaxel in combination with intra-arterial infusion of adriamycin', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 28, no. 2, pp. 229-233.
Doihara, Hiroyoshi ; Yoshitomi, S. ; Hino, M. ; Teramoto, A. ; Ishibe, Y. ; Ogasawara, Y. ; Nagahiro, I. ; Sano, Y. ; Shimizu, N. / Two cases of advanced and metastatic breast cancers treated by docetaxel in combination with intra-arterial infusion of adriamycin. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2001 ; Vol. 28, No. 2. pp. 229-233.
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