Two cases of advanced and metastatic breast cancers treated by docetaxel in combination with intra-arterial infusion of adriamycin

H. Doihara, S. Yoshitomi, M. Hino, A. Teramoto, Y. Ishibe, Y. Ogasawara, I. Nagahiro, Y. Sano, N. Shimizu

Research output: Contribution to journalArticle

Abstract

Two cases of advanced and metastatic breast cancers were treated by docetaxel (TXT) in combination with intra-arterial infusion of adriamycin (ADM). Patients received 60 mg/body TXT i.v. and 30 mg/body ADM ia (AT therapy) bi-weekly. Clinical responses were observed in these two patients and the durations of responses were over 20 weeks. Critical toxicities of grade 2 leukopenia and alopecia were observed but grade 4 severe toxicities were not. Thus AT therapy can be easily and safely performed with outpatients. This therapy can improve the response rate and time to progression; therefore phase I or phase I/II clinical trials of AT therapy in Japan are recommended.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume28
Issue number2
Publication statusPublished - Feb 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Doihara, H., Yoshitomi, S., Hino, M., Teramoto, A., Ishibe, Y., Ogasawara, Y., Nagahiro, I., Sano, Y., & Shimizu, N. (2001). Two cases of advanced and metastatic breast cancers treated by docetaxel in combination with intra-arterial infusion of adriamycin. Gan to kagaku ryoho. Cancer & chemotherapy, 28(2), 229-233.