Tumorigenic development of induced pluripotent stem cells in ischemic mouse brain

Toru Yamashita, Hiromi Kawai, Fengfeng Tian, Yasuyuki Ohta, Koji Abe

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Induced pluripotent stem (iPS) cells may provide cures for various neurological diseases. However, undifferentiated iPS cells have high tumorigenicity, and evaluation of the cells fates, especially in pathologic condition model, is needed. In this study, we demonstrated the effect of ischemic condition to undifferentiated iPS cells fates in a mouse model of transient middle cerebral artery occlusion (MCAO). Undifferentiated iPS cells were characterized with immunofluorescent staining. The iPS cells (5 ×10 5) were injected into ipsilateral striatum and cortex after 24 h of MCAO. Histological analysis was performed from 3 to 28 days after cell transplantation. iPS cells in ischemic brain formed teratoma with higher probability (p

Original languageEnglish
Pages (from-to)883-891
Number of pages9
JournalCell Transplantation
Volume20
Issue number6
DOIs
Publication statusPublished - 2011

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Induced Pluripotent Stem Cells
Stem cells
Brain
Middle Cerebral Artery Infarction
Teratoma
Cell Transplantation
Staining and Labeling

Keywords

  • Cell transplantation
  • Cerebral ischemia
  • Induced pluripotent stem (iPS) cells
  • Tumorigenesis

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering

Cite this

Tumorigenic development of induced pluripotent stem cells in ischemic mouse brain. / Yamashita, Toru; Kawai, Hiromi; Tian, Fengfeng; Ohta, Yasuyuki; Abe, Koji.

In: Cell Transplantation, Vol. 20, No. 6, 2011, p. 883-891.

Research output: Contribution to journalArticle

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