Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice

Shinji Miwa, Shuya Yano, Yong Zhang, Yasunori Matsumoto, Fuminari Uehara, Mako Yamamoto, Yukihiko Hiroshima, Hiroaki Kimura, Katsuhiro Hayashi, Norio Yamamoto, Michael Bouvet, Hiroyuki Tsuchiya, Robert M. Hoffman, Ming Zhao

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Bone metastasis is a lethal and morbid late stage of breast cancer that is currently treatment resistant. More effective mouse models and treatment are necessary. High bone-metastatic variants of human breast cancer cells were selected in nude mice by cardiac injection. After cardiac injection of a high bone-metastatic variant of breast cancer, all untreated mice had bone metastases compared to only 20% with parental cells. Treatment with tumor-targeting Salmonella typhimurium A1-R completely prevented the appearance of bone metastasis of the high metastatic variant in nude mice (P < 0.001). After injection of the highly bone-metastatic breast cancer variant to the tibia of nude mice, S. typhimurium A1-R treatment significantly reduced tumor growth in the bone (P < 0.001). These data indicated that S. typhimurium A1-R is useful to prevent and inhibit breast cancer bone metastasis and should be of future clinical use for breast cancer in the adjuvant setting.

Original languageEnglish
Pages (from-to)7119-7125
Number of pages7
JournalOncotarget
Volume5
Issue number16
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Bacterial therapy
  • Bone metastasis
  • Breast cancer
  • GFP
  • RFP
  • Salmonella typhimurium A1-R

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Miwa, S., Yano, S., Zhang, Y., Matsumoto, Y., Uehara, F., Yamamoto, M., Hiroshima, Y., Kimura, H., Hayashi, K., Yamamoto, N., Bouvet, M., Tsuchiya, H., Hoffman, R. M., & Zhao, M. (2014). Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. Oncotarget, 5(16), 7119-7125. https://doi.org/10.18632/oncotarget.2226