Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report

Kohji Tanakaya, Nobuhiko Kanaya, Kunitoshi Shigeyasu, Tomoyoshi Kunitomo, Hideki Aoki, Hitoshi Takeuchi, Rie Yamasaki

Research output: Contribution to journalArticle

Abstract

Lynch syndrome is an inherited syndrome associated with the development of colorectal and various other cancers. A 65-year-old male underwent a laparoscopic-assisted right hemi-colectomy for ascending colon cancer (cStage II). Histologically, his tumor was diagnosed as a poorly differentiated adenocarcinoma. Lymphocytic reactions, such as tumor-infiltrating lymphocytes (TIL), and Crohn's-like reactions, were observed. Genetic testing revealed the presence of a pathogenic mutation in the MLH1. In the Lynch syndrome, the most frequently observed findings include the accumulation of mutations, and an early onset of familial colon cancer. Although the case presented here did not show the typical clinical findings of Lynch syndrome, histological examination of the lymphocytic reactions proved useful for screening for Lynch syndrome. Herein, we establish the important role of the pathologist in alerting the clinician to the possibility of Lynch syndrome when the findings of TIL and Crohn's-like reactions are detected.

Original languageEnglish
Pages (from-to)1602-1604
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number12
Publication statusPublished - Nov 2014
Externally publishedYes

Fingerprint

Tumor-Infiltrating Lymphocytes
Hereditary Nonpolyposis Colorectal Neoplasms
Colonic Neoplasms
Ascending Colon
Colectomy
Genetic Testing
Neoplasms
Adenocarcinoma
Mutation

Keywords

  • Lynch syndrome
  • Screening
  • Tumor-infiltrating lymphocyte

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Tanakaya, K., Kanaya, N., Shigeyasu, K., Kunitomo, T., Aoki, H., Takeuchi, H., & Yamasaki, R. (2014). Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report. Japanese Journal of Cancer and Chemotherapy, 41(12), 1602-1604.

Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report. / Tanakaya, Kohji; Kanaya, Nobuhiko; Shigeyasu, Kunitoshi; Kunitomo, Tomoyoshi; Aoki, Hideki; Takeuchi, Hitoshi; Yamasaki, Rie.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 41, No. 12, 11.2014, p. 1602-1604.

Research output: Contribution to journalArticle

Tanakaya, K, Kanaya, N, Shigeyasu, K, Kunitomo, T, Aoki, H, Takeuchi, H & Yamasaki, R 2014, 'Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report', Japanese Journal of Cancer and Chemotherapy, vol. 41, no. 12, pp. 1602-1604.
Tanakaya, Kohji ; Kanaya, Nobuhiko ; Shigeyasu, Kunitoshi ; Kunitomo, Tomoyoshi ; Aoki, Hideki ; Takeuchi, Hitoshi ; Yamasaki, Rie. / Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report. In: Japanese Journal of Cancer and Chemotherapy. 2014 ; Vol. 41, No. 12. pp. 1602-1604.
@article{335c9e3d6f3f4716b4d931264bec687d,
title = "Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report",
abstract = "Lynch syndrome is an inherited syndrome associated with the development of colorectal and various other cancers. A 65-year-old male underwent a laparoscopic-assisted right hemi-colectomy for ascending colon cancer (cStage II). Histologically, his tumor was diagnosed as a poorly differentiated adenocarcinoma. Lymphocytic reactions, such as tumor-infiltrating lymphocytes (TIL), and Crohn's-like reactions, were observed. Genetic testing revealed the presence of a pathogenic mutation in the MLH1. In the Lynch syndrome, the most frequently observed findings include the accumulation of mutations, and an early onset of familial colon cancer. Although the case presented here did not show the typical clinical findings of Lynch syndrome, histological examination of the lymphocytic reactions proved useful for screening for Lynch syndrome. Herein, we establish the important role of the pathologist in alerting the clinician to the possibility of Lynch syndrome when the findings of TIL and Crohn's-like reactions are detected.",
keywords = "Lynch syndrome, Screening, Tumor-infiltrating lymphocyte",
author = "Kohji Tanakaya and Nobuhiko Kanaya and Kunitoshi Shigeyasu and Tomoyoshi Kunitomo and Hideki Aoki and Hitoshi Takeuchi and Rie Yamasaki",
year = "2014",
month = "11",
language = "English",
volume = "41",
pages = "1602--1604",
journal = "Japanese Journal of Cancer and Chemotherapy",
issn = "0385-0684",
publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",
number = "12",

}

TY - JOUR

T1 - Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report

AU - Tanakaya, Kohji

AU - Kanaya, Nobuhiko

AU - Shigeyasu, Kunitoshi

AU - Kunitomo, Tomoyoshi

AU - Aoki, Hideki

AU - Takeuchi, Hitoshi

AU - Yamasaki, Rie

PY - 2014/11

Y1 - 2014/11

N2 - Lynch syndrome is an inherited syndrome associated with the development of colorectal and various other cancers. A 65-year-old male underwent a laparoscopic-assisted right hemi-colectomy for ascending colon cancer (cStage II). Histologically, his tumor was diagnosed as a poorly differentiated adenocarcinoma. Lymphocytic reactions, such as tumor-infiltrating lymphocytes (TIL), and Crohn's-like reactions, were observed. Genetic testing revealed the presence of a pathogenic mutation in the MLH1. In the Lynch syndrome, the most frequently observed findings include the accumulation of mutations, and an early onset of familial colon cancer. Although the case presented here did not show the typical clinical findings of Lynch syndrome, histological examination of the lymphocytic reactions proved useful for screening for Lynch syndrome. Herein, we establish the important role of the pathologist in alerting the clinician to the possibility of Lynch syndrome when the findings of TIL and Crohn's-like reactions are detected.

AB - Lynch syndrome is an inherited syndrome associated with the development of colorectal and various other cancers. A 65-year-old male underwent a laparoscopic-assisted right hemi-colectomy for ascending colon cancer (cStage II). Histologically, his tumor was diagnosed as a poorly differentiated adenocarcinoma. Lymphocytic reactions, such as tumor-infiltrating lymphocytes (TIL), and Crohn's-like reactions, were observed. Genetic testing revealed the presence of a pathogenic mutation in the MLH1. In the Lynch syndrome, the most frequently observed findings include the accumulation of mutations, and an early onset of familial colon cancer. Although the case presented here did not show the typical clinical findings of Lynch syndrome, histological examination of the lymphocytic reactions proved useful for screening for Lynch syndrome. Herein, we establish the important role of the pathologist in alerting the clinician to the possibility of Lynch syndrome when the findings of TIL and Crohn's-like reactions are detected.

KW - Lynch syndrome

KW - Screening

KW - Tumor-infiltrating lymphocyte

UR - http://www.scopus.com/inward/record.url?scp=84949190296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949190296&partnerID=8YFLogxK

M3 - Article

C2 - 25731267

AN - SCOPUS:84949190296

VL - 41

SP - 1602

EP - 1604

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

IS - 12

ER -