Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide

Tomonori Yanagawa, Tomomi Noguchi, Hiroyuki Miyachi, Hisayoshi Kobayashi, Yuichi Hashimoto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

4,7-Difluoro-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [4,7FPP-33 (14)] has a potent tubulin-polymerization-inhibiting activity comparable with those of the known tubulin-polymerization inhibitors rhizoxin and colchicine. The structure-activity relationship for fluorine substitution was elucidated.

Original languageEnglish
Pages (from-to)4748-4751
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number18
DOIs
Publication statusPublished - Sep 15 2006

Keywords

  • Fluorophthalimide
  • Thalidomide
  • Tubulin
  • Tubulin polymerization inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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