TY - JOUR
T1 - Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide
AU - Yanagawa, Tomonori
AU - Noguchi, Tomomi
AU - Miyachi, Hiroyuki
AU - Kobayashi, Hisayoshi
AU - Hashimoto, Yuichi
N1 - Funding Information:
The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science.
PY - 2006/9/15
Y1 - 2006/9/15
N2 - 4,7-Difluoro-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [4,7FPP-33 (14)] has a potent tubulin-polymerization-inhibiting activity comparable with those of the known tubulin-polymerization inhibitors rhizoxin and colchicine. The structure-activity relationship for fluorine substitution was elucidated.
AB - 4,7-Difluoro-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [4,7FPP-33 (14)] has a potent tubulin-polymerization-inhibiting activity comparable with those of the known tubulin-polymerization inhibitors rhizoxin and colchicine. The structure-activity relationship for fluorine substitution was elucidated.
KW - Fluorophthalimide
KW - Thalidomide
KW - Tubulin
KW - Tubulin polymerization inhibitor
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U2 - 10.1016/j.bmcl.2006.06.091
DO - 10.1016/j.bmcl.2006.06.091
M3 - Article
C2 - 16870433
AN - SCOPUS:33746802786
VL - 16
SP - 4748
EP - 4751
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 18
ER -