Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide

Tomonori Yanagawa, Tomomi Noguchi, Hiroyuki Miyachi, Hisayoshi Kobayashi, Yuichi Hashimoto

Research output: Contribution to journal › Article

13 Citations (Scopus)

Abstract

4,7-Difluoro-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [4,7FPP-33 (14)] has a potent tubulin-polymerization-inhibiting activity comparable with those of the known tubulin-polymerization inhibitors rhizoxin and colchicine. The structure-activity relationship for fluorine substitution was elucidated.

Original languageEnglish
Pages (from-to)4748-4751
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number18
DOIs
Publication statusPublished - Sep 15 2006
Externally publishedYes

Fingerprint

Tubulin Modulators
Thalidomide
Fluorine
Colchicine
Structure-Activity Relationship
Tubulin
Skeleton
Polymerization
Substitution reactions
rhizoxin
2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
phthalimide

Keywords

  • Fluorophthalimide
  • Thalidomide
  • Tubulin
  • Tubulin polymerization inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide. / Yanagawa, Tomonori; Noguchi, Tomomi; Miyachi, Hiroyuki; Kobayashi, Hisayoshi; Hashimoto, Yuichi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 18, 15.09.2006, p. 4748-4751.

Research output: Contribution to journal › Article

Yanagawa, T, Noguchi, T, Miyachi, H, Kobayashi, H & Hashimoto, Y 2006, 'Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide', Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 18, pp. 4748-4751. https://doi.org/10.1016/j.bmcl.2006.06.091
Yanagawa T, Noguchi T, Miyachi H, Kobayashi H, Hashimoto Y. Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide. Bioorganic and Medicinal Chemistry Letters. 2006 Sep 15;16(18):4748-4751. https://doi.org/10.1016/j.bmcl.2006.06.091
Yanagawa, Tomonori ; Noguchi, Tomomi ; Miyachi, Hiroyuki ; Kobayashi, Hisayoshi ; Hashimoto, Yuichi. / Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 18. pp. 4748-4751.
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AU - Hashimoto, Yuichi

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