Abstract
4,7-Difluoro-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [4,7FPP-33 (14)] has a potent tubulin-polymerization-inhibiting activity comparable with those of the known tubulin-polymerization inhibitors rhizoxin and colchicine. The structure-activity relationship for fluorine substitution was elucidated.
| Original language | English |
|---|---|
| Pages (from-to) | 4748-4751 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 16 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - Sep 15 2006 |
Keywords
- Fluorophthalimide
- Thalidomide
- Tubulin
- Tubulin polymerization inhibitor
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Yanagawa, T., Noguchi, T., Miyachi, H., Kobayashi, H., & Hashimoto, Y. (2006). Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide. Bioorganic and Medicinal Chemistry Letters, 16(18), 4748-4751. https://doi.org/10.1016/j.bmcl.2006.06.091