Trophinin is expressed in the porcine endometrium during the estrous cycle

Saeko Nakano, Hisashi Kishi, Hidehiko Ogawa, Hiroshi Yasue, Akira Okano, Kiyoshi Okuda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated endometrial expression of trophinin mRNA and protein, homophilic cell adhesion molecules, during the estrous cycle of gilts. An immunopositive reaction for trophinin was observed in the luminal and glandular epithelia of the endometrium at all stages of the estrous cycle, but not in endometrial stromal cells or the myometrium. A partial coding sequence of porcine trophinin was similar to sequences in humans and mice, with homologies of 75% and 70%, respectively. As in humans and mice, the trophinin gene is expressed in the endometrium. Trophinin, however, is expressed in the endometrium of the pig throughout the estrous cycle, higher expression levels were observed at some points of the luteal phase, as in humans. These findings suggest that regulation of trophinin gene expression in the pig is different from that in mice, but similar to that in humans. Furthermore, the present results suggest that the pig might be a suitable model for studying the physiological importance of trophinin in early pregnancy in humans.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalJournal of Reproduction and Development
Volume49
Issue number2
Publication statusPublished - 2003

Fingerprint

Estrous Cycle
endometrium
Endometrium
estrous cycle
Swine
swine
mice
myometrium
Myometrium
stromal cells
Luteal Phase
gene expression regulation
Cell Adhesion Molecules
Gene Expression Regulation
Stromal Cells
corpus luteum
cell adhesion
gilts
epithelium
Epithelium

Keywords

  • Endometrium
  • Gilt
  • Semi-quantitative assay
  • Trophinin

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Reproductive Medicine

Cite this

Nakano, S., Kishi, H., Ogawa, H., Yasue, H., Okano, A., & Okuda, K. (2003). Trophinin is expressed in the porcine endometrium during the estrous cycle. Journal of Reproduction and Development, 49(2), 127-134.

Trophinin is expressed in the porcine endometrium during the estrous cycle. / Nakano, Saeko; Kishi, Hisashi; Ogawa, Hidehiko; Yasue, Hiroshi; Okano, Akira; Okuda, Kiyoshi.

In: Journal of Reproduction and Development, Vol. 49, No. 2, 2003, p. 127-134.

Research output: Contribution to journalArticle

Nakano, S, Kishi, H, Ogawa, H, Yasue, H, Okano, A & Okuda, K 2003, 'Trophinin is expressed in the porcine endometrium during the estrous cycle', Journal of Reproduction and Development, vol. 49, no. 2, pp. 127-134.
Nakano S, Kishi H, Ogawa H, Yasue H, Okano A, Okuda K. Trophinin is expressed in the porcine endometrium during the estrous cycle. Journal of Reproduction and Development. 2003;49(2):127-134.
Nakano, Saeko ; Kishi, Hisashi ; Ogawa, Hidehiko ; Yasue, Hiroshi ; Okano, Akira ; Okuda, Kiyoshi. / Trophinin is expressed in the porcine endometrium during the estrous cycle. In: Journal of Reproduction and Development. 2003 ; Vol. 49, No. 2. pp. 127-134.
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