Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

Kensuke Kojima, Masafumi Taniwaki, Tadashi Yoshino, Yoshio Katayama, Kazutaka Sunami, Syunnichi Fukuda, Eijiro Omoto, Mine Harada, Tatsuo Sezaki

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15 Citations (Scopus)

Abstract

We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement, occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cells with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalInternational journal of hematology
Volume67
Issue number2
Publication statusPublished - Feb 1998

Keywords

  • B-cell chronic lymphocytic leukemia (B-CLL)
  • Fluorescence in situ hybridization (FISH)
  • Major breakpoint region
  • T(14;18)
  • Trisomy 12

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Kojima, K., Taniwaki, M., Yoshino, T., Katayama, Y., Sunami, K., Fukuda, S., Omoto, E., Harada, M., & Sezaki, T. (1998). Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia. International journal of hematology, 67(2), 199-203.