Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

Kensuke Kojima; Masafumi Taniwaki; Tadashi Yoshino; Yoshio Katayama; Kazutaka Sunami; Syunnichi Fukuda; Eijiro Omoto; Mine Harada; Tatsuo Sezaki

doi:10.1016/s0925-5710(97)00110-2

Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

Kensuke Kojima, Masafumi Taniwaki, Tadashi Yoshino, Yoshio Katayama, Kazutaka Sunami, Syunnichi Fukuda, Eijiro Omoto, Mine Harada, Tatsuo Sezaki

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement, occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cells with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.

Original language	English
Pages (from-to)	199-203
Number of pages	5
Journal	International journal of hematology
Volume	67
Issue number	2
DOIs	https://doi.org/10.1016/s0925-5710(97)00110-2
Publication status	Published - Feb 1998

Keywords

B-cell chronic lymphocytic leukemia (B-CLL)
Fluorescence in situ hybridization (FISH)
Major breakpoint region
T(14;18)
Trisomy 12

ASJC Scopus subject areas

Hematology

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title = "Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia",

abstract = "We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement, occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cells with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.",

keywords = "B-cell chronic lymphocytic leukemia (B-CLL), Fluorescence in situ hybridization (FISH), Major breakpoint region, T(14;18), Trisomy 12",

author = "Kensuke Kojima and Masafumi Taniwaki and Tadashi Yoshino and Yoshio Katayama and Kazutaka Sunami and Syunnichi Fukuda and Eijiro Omoto and Mine Harada and Tatsuo Sezaki",

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AU - Kojima, Kensuke

AU - Taniwaki, Masafumi

AU - Yoshino, Tadashi

AU - Katayama, Yoshio

AU - Sunami, Kazutaka

AU - Fukuda, Syunnichi

AU - Omoto, Eijiro

AU - Harada, Mine

AU - Sezaki, Tatsuo

PY - 1998/2

Y1 - 1998/2

N2 - We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement, occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cells with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.

AB - We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement, occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cells with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.

KW - B-cell chronic lymphocytic leukemia (B-CLL)

KW - Fluorescence in situ hybridization (FISH)

KW - Major breakpoint region

KW - T(14;18)

KW - Trisomy 12

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JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

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Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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