Abstract
We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement, occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cells with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.
| Original language | English |
|---|---|
| Pages (from-to) | 199-203 |
| Number of pages | 5 |
| Journal | International journal of hematology |
| Volume | 67 |
| Issue number | 2 |
| Publication status | Published - Feb 1998 |
Keywords
- B-cell chronic lymphocytic leukemia (B-CLL)
- Fluorescence in situ hybridization (FISH)
- Major breakpoint region
- T(14;18)
- Trisomy 12
ASJC Scopus subject areas
- Hematology
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Cite this
Kojima, K., Taniwaki, M., Yoshino, T., Katayama, Y., Sunami, K., Fukuda, S., Omoto, E., Harada, M., & Sezaki, T. (1998). Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia. International journal of hematology, 67(2), 199-203.