Triple tSMS system (“SHIN jiba”) for non-invasive deep brain stimulation: a validation study in healthy subjects

Sumiya Shibata, Tatsunori Watanabe, Takuya Matsumoto, Keisuke Yunoki, Takayuki Horinouchi, Hikari Kirimoto, Jianxu Zhang, Hen Wang, Jinglong Wu, Hideaki Onishi, Tatsuya Mima

Research output: Contribution to journalArticlepeer-review


Background: Transcranial static magnetic field stimulation (tSMS) using a small and strong neodymium (NdFeB) magnet can temporarily suppress brain functions below the magnet. It is a promising non-invasive brain stimulation modality because of its competitive advantages such as safety, simplicity, and low-cost. However, current tSMS is insufficient to effectively stimulate deep brain areas due to attenuation of the magnetic field with the distance from the magnet. The aim of this study was to develop a brand-new tSMS system for non-invasive deep brain stimulation. Methods: We designed and fabricated a triple tSMS system with three cylindrical NdFeB magnets placed close to each other. We compared the strength of magnetic field produced by the triple tSMS system with that by the current tSMS. Furthermore, to confirm its function, we stimulated the primary motor area in 17 healthy subjects with the triple tSMS for 20 min and assessed the cortical excitability using the motor evoked potential (MEP) obtained by transcranial magnetic stimulation. Results: Our triple tSMS system produced the magnetic field sufficient for neuromodulation up to 80 mm depth from the magnet surface, which was 30 mm deeper than the current tSMS system. In the stimulation experiment, the triple tSMS significantly reduced the MEP amplitude, demonstrating a successful inhibition of the M1 excitability in healthy subjects. Conclusion: Our triple tSMS system has an ability to produce an effective magnetic field in deep areas and to modulate the brain functions. It can be used for non-invasive deep brain stimulation.

Original languageEnglish
Article number129
JournalJournal of NeuroEngineering and Rehabilitation
Issue number1
Publication statusPublished - Dec 2022


  • Deep brain stimulation
  • Neodymium magnet
  • Non-invasive brain stimulation
  • SHIN jiba
  • Transcranial static magnetic field stimulation

ASJC Scopus subject areas

  • Rehabilitation
  • Health Informatics


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