Treatment with sulbactam/cefoperazone of severe infections in patients with hematological disorders

Ryuzo Ohno, Tomomitsu Hotta, Michinori Ogura, Kazunori Ohnishi, Takehisa Morishita, Takashi Murate, Masao Okumura, Mitsune Tanimoto, Chikako Inoue, Motohiro Hamaguchi, Atsushi Ichikawa, Seiichi Gotoh, Hidehiko Saito, Noriyuki Hirabayashi, Keitaro Tsushita, Hideo Takeyama, Hironori Yamada, Takaaki Takeo, Shozo Yokomaku, Kanji OgataToshimasa Nagai, Harumitsu Mizuno, Hisami Yamao, Kyuzo Suzuki, Takae Kataoka, Yutaka Hirota, Masao Tanaka, Yasumitsu Nakaide, Yoshihisa Fujiwara, Takuhei Murase, Hirokazu Nagai, Jiro Inagaki, Kouichi Nakamura, Noboru Tanabe, Makoto Utsumi

Research output: Contribution to journalArticle

Abstract

Infectious episodes in 90 patients with hematological disorders were treated with sulbactam/ cefoperazone (SBT/CPZ), a new combination drug of a potent β-lactamase inhibitor, sodium sulbactam, and a third generation cephalosporin, sodium cefoperazone. Clinical responses to the SBT/CPZ regimen were excellent in 23 cases, good in 30 cases, fair in 11 cases, and poor in 26 cases. The overall efficacy rate (percentage of cases showing excellent or good responses) was 5S.9%. Efficacy rates classified according to different infections were: 80% in documented sepsis, 57.6% in suspected sepsis, 61.1% in pneumonia and 50% in other infections. One episode of side effect was encountered with redness and itching of skin. Hepatic disorders were observed in 3 cases. These adverse reactions, however, were not serious. These results indicate that SBT/CPZ has a high therapeutic efficacy to severe infections in patients with hematological disorders.

Original languageEnglish
Pages (from-to)1713-1719
Number of pages7
JournalThe Japanese journal of antibiotics
Volume42
Issue number8
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Ohno, R., Hotta, T., Ogura, M., Ohnishi, K., Morishita, T., Murate, T., Okumura, M., Tanimoto, M., Inoue, C., Hamaguchi, M., Ichikawa, A., Gotoh, S., Saito, H., Hirabayashi, N., Tsushita, K., Takeyama, H., Yamada, H., Takeo, T., Yokomaku, S., ... Utsumi, M. (1989). Treatment with sulbactam/cefoperazone of severe infections in patients with hematological disorders. The Japanese journal of antibiotics, 42(8), 1713-1719. https://doi.org/10.11553/antibiotics1968b.42.1713