Treatment with sulbactam/cefoperazone of severe infections in patients with hematological disorders

R. Ohno, T. Hotta, M. Ogura, K. Ohnishi, T. Morishita, T. Murate, M. Okumura, M. Tanimoto, C. Inoue, M. Hamaguchi, A. Ichikawa, S. Gotoh, H. Saito, N. Hirabayashi, K. Tsushita, H. Takeyama, H. Yamada, T. Takeo, S. Yokomaku

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Abstract

Infectious episodes in 90 patients with hematological disorders were treated with sulbactam/cefoperazone (SBT/CPZ), a new combination drug of a potent β-lactamase inhibitor, sodium sulbactam, and a third generation cephalosporin, sodium cefoperazone. Clinical responses to the SBT/CPZ regimen were excellent in 23 cases, good in 30 cases, fair in 11 cases, and poor in 26 cases. The overall efficacy rate (percentage of cases showing excellent or good responses) was 58.9%. Efficacy rates classified according to different infections were: 80% in documented sepsis, 57.6% in suspected sepsis, 61.1% in pneumonia and 50% in other infections. One episode of side effect was encountered with redness and itching of skin. Hepatic disorders were observed in 3 cases. These adverse reactions, however, were not serious. These results indicate that SBT/CPZ has a high therapeutic efficacy to severe infections in patients with hematological disorders.

Original languageEnglish
Pages (from-to)1713-1719
Number of pages7
JournalJapanese Journal of Antibiotics
Volume42
Issue number8
Publication statusPublished - 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Ohno, R., Hotta, T., Ogura, M., Ohnishi, K., Morishita, T., Murate, T., Okumura, M., Tanimoto, M., Inoue, C., Hamaguchi, M., Ichikawa, A., Gotoh, S., Saito, H., Hirabayashi, N., Tsushita, K., Takeyama, H., Yamada, H., Takeo, T., & Yokomaku, S. (1989). Treatment with sulbactam/cefoperazone of severe infections in patients with hematological disorders. Japanese Journal of Antibiotics, 42(8), 1713-1719.