Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter

S. N. Laxmi, S. Takahashi, K. Matsumoto, S. Higano, N. Kurihara, M. Imaizumi, Koji Abe, Y. Itoyama, K. Sakamoto

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Abstract

This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the vertex. Necropsy of the first case revealed loss of myelination and necrosis of the white matter. Possible mechanisms causing such a leukoencephalopathy are discussed.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume14
Issue number6
Publication statusPublished - 1996
Externally publishedYes

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Keywords

  • leukoencephalopathy
  • methotrexate
  • MR imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Laxmi, S. N., Takahashi, S., Matsumoto, K., Higano, S., Kurihara, N., Imaizumi, M., Abe, K., Itoyama, Y., & Sakamoto, K. (1996). Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter. Radiation Medicine - Medical Imaging and Radiation Oncology, 14(6), 303-307.