Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter

S. N. Laxmi; S. Takahashi; K. Matsumoto; S. Higano; N. Kurihara; M. Imaizumi; K. Abe; Y. Itoyama; K. Sakamoto

Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter

S. N. Laxmi, S. Takahashi, K. Matsumoto, S. Higano, N. Kurihara, M. Imaizumi, K. Abe, Y. Itoyama, K. Sakamoto

Research output: Contribution to journal › Article › peer-review

Abstract

This report describes unique contrast enhancement of the white matter on T₁-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the vertex. Necropsy of the first case revealed loss of myelination and necrosis of the white matter. Possible mechanisms causing such a leukoencephalopathy are discussed.

Original language	English
Pages (from-to)	303-307
Number of pages	5
Journal	Radiation Medicine - Medical Imaging and Radiation Oncology
Volume	14
Issue number	6
Publication status	Published - Dec 1 1996
Externally published	Yes

Keywords

MR imaging
leukoencephalopathy
methotrexate

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging
Oncology

Cite this

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title = "Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter",

abstract = "This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the vertex. Necropsy of the first case revealed loss of myelination and necrosis of the white matter. Possible mechanisms causing such a leukoencephalopathy are discussed.",

keywords = "MR imaging, leukoencephalopathy, methotrexate",

author = "Laxmi, {S. N.} and S. Takahashi and K. Matsumoto and S. Higano and N. Kurihara and M. Imaizumi and K. Abe and Y. Itoyama and K. Sakamoto",

year = "1996",

month = dec,

day = "1",

language = "English",

volume = "14",

pages = "303--307",

journal = "Japanese Journal of Radiology",

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T1 - Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter

AU - Laxmi, S. N.

AU - Takahashi, S.

AU - Matsumoto, K.

AU - Higano, S.

AU - Kurihara, N.

AU - Imaizumi, M.

AU - Abe, K.

AU - Itoyama, Y.

AU - Sakamoto, K.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the vertex. Necropsy of the first case revealed loss of myelination and necrosis of the white matter. Possible mechanisms causing such a leukoencephalopathy are discussed.

AB - This report describes unique contrast enhancement of the white matter on T1-weighted magnetic resonance images of two patients with disseminated necrotizing leukoencephalopathy, which developed acute lymphoblastic leukemia treated with high-dose methotrexate. In both patients, the enhancement was more pronounced near the base of the brain than at the vertex. Necropsy of the first case revealed loss of myelination and necrosis of the white matter. Possible mechanisms causing such a leukoencephalopathy are discussed.

KW - MR imaging

KW - leukoencephalopathy

KW - methotrexate

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AN - SCOPUS:0030448911

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JO - Japanese Journal of Radiology

JF - Japanese Journal of Radiology

IS - 6

ER -

Treatment-related disseminated necrotizing leukoencephalopathy with characteristic contrast enhancement of the white matter

Abstract

Keywords

ASJC Scopus subject areas

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