Treatment outcomes of proton or carbon ion therapy for skull base chordoma: a retrospective study

Masaru Takagi, Yusuke Demizu, Fumiko Nagano, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Masayuki Mima, Yasue Niwa, Kuniaki Katsui, Masaki Suga, Tomohiro Yamashita, Takashi Akagi, Koh ichi Sakata, Nobukazu Fuwa, Tomoaki Okimoto

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21 Citations (Scopus)


Background: The usefulness of particle therapy for skull base chordoma has not been established. The aim of this retrospective study was to analyse the treatment outcomes of proton therapy (PT) and carbon ion therapy (CIT) in patients with skull base chordoma at a single institution. Methods: All patients who underwent PT or CIT with curative intent between 2003 and 2014 at Hyogo Ion Beam Medical Center were included in this study. Twenty-four patients were enrolled. Eleven (46%) received PT and 13 (54%) received CIT. Overall survival (OS), progression-free survival (PFS) and local control (LC) were calculated using the Kaplan-Meier method. Late toxicities were evaluated according to the Common Terminology Criteria for Adverse Events version 4.0. Results: The median follow-up was 71.5 months (range, 14-175 months). The five-year LC, PFS and OS rates were 85, 81, and 86%, respectively. The LC (P = 0.048), PFS (P = 0.028) and OS (P = 0.012) were significantly improved in patients who had undergone surgery before particle therapy. No significant differences were observed in the LC rate and the incidence of grade 2 or higher late toxicities between patients who received PT and CIT. Conclusions: Both PT and CIT appear to be effective and safe treatments and show potential to become the standard treatments for skull base chordoma. To increase the local control, surgery before particle therapy is preferable.

Original languageEnglish
Article number232
JournalRadiation Oncology
Issue number1
Publication statusPublished - Nov 26 2018


  • Carbon ion therapy
  • Late toxicity
  • Local control
  • Proton therapy
  • Radiotherapy
  • Skull base chordoma
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


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